Maternal and paternal exercise regulate offspring metabolic health and beta cell phenotype
Maternal and paternal exercise regulate offspring metabolic health and beta cell phenotype
复制标题
母亲和父亲的运动调节后代代谢健康和 β 细胞表型
DOI：
10.1136/bmjdrc-2019-000890
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发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Laurie J Goodyear
中科院分区：
文献类型：
--
作者：
Jia Zheng;Ana Barbara Alves-Wagner;Kristin I Stanford;Noah B Prince;Kawai So;Joram D Mul;Ercument Dirice;Michael F Hirshman;Rohit N Kulkarni;Laurie J Goodyear
目的研究母鼠和母鼠的不良生活环境对子代肥胖和糖尿病的影响，而母鼠和母鼠的运动可以改善子代的代谢健康。我们确定了母亲和父亲联合锻炼对后代健康的影响，以及父母锻炼对后代胰腺表型的影响，胰腺是调节葡萄糖稳态的主要组织。研究设计和方法在繁殖前（雄性）和妊娠前和妊娠期间（雌性），对繁殖动物进行高脂肪喂养和圈养±转轮。后代组为：父母双方久坐（Sed）;仅母亲锻炼（Mat Ex）;仅父亲锻炼（Pat Ex）;以及母亲+父亲锻炼（Mat+Pat Ex）。后代是久坐不动的，食物喂养，并在断奶，12，20和52周的研究。结果虽然父母锻炼对年轻时的葡萄糖耐量没有影响，但在52周时，Mat Ex，Pat Ex和Mat+Pat Ex的后代显示出较低的血糖和改善的葡萄糖耐量。最大的影响是在后代的父母都行使（垫+帕特前）。Mat Ex、Pat Ex和Mat+Pat Ex的后代具有减小的β细胞大小，而胰岛大小和β细胞质量仅在Mat+Pat Ex后代中减小。结论随年龄增长，母亲和父亲运动对后代糖耐量的改善具有累加效应，并伴随着后代胰腺内分泌的变化。这些发现对2型糖尿病的预防和治疗具有重要意义。
Objective Poor maternal and paternal environments increase the risk for obesity and diabetes in offspring, whereas maternal and paternal exercise in mice can improve offspring metabolic health. We determined the effects of combined maternal and paternal exercise on offspring health and the effects of parental exercise on offspring pancreas phenotype, a major tissue regulating glucose homeostasis. Research design and methods Breeders were high fat fed and housed±running wheels before breeding (males) and before and during gestation (females). Offspring groups were: both parents sedentary (Sed); maternal exercise only (Mat Ex); paternal exercise only (Pat Ex); and maternal+paternal exercise (Mat+Pat Ex). Offspring were sedentary, chow fed, and studied at weaning, 12, 20 and 52 weeks. Results While there was no effect of parental exercise on glucose tolerance at younger ages, at 52 weeks, offspring of Mat Ex, Pat Ex and Mat+Pat Ex displayed lower glycemia and improved glucose tolerance. The greatest effects were in offspring from parents that both exercised (Mat+Pat Ex). Offspring from Mat Ex, Pat Ex, and Mat+Pat Ex had decreased beta cell size, whereas islet size and beta cell mass only decreased in Mat+Pat Ex offspring. Conclusions Maternal and paternal exercise have additive effects to improve glucose tolerance in offspring as they age, accompanied by changes in the offspring endocrine pancreas. These findings have important implications for the prevention and treatment of type 2 diabetes.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
4.1
作者：
Carter LG;Qi NR;De Cabo R;Pearson KJ
通讯作者：
Pearson KJ
影响因子：
29
作者：
Sales VM;Ferguson-Smith AC;Patti ME
通讯作者：
Patti ME
DOI：
10.1113/jp276762
发表时间：
2018-08
期刊：
The Journal of Physiology
影响因子：
--
作者：
A. Forhead
通讯作者：
A. Forhead
DOI：
10.1038/ijo.2017.44
发表时间：
2017-07
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Patel N;Godfrey KM;Pasupathy D;Levin J;Flynn AC;Hayes L;Briley AL;Bell R;Lawlor DA;Oteng-Ntim E;Nelson SM;Robson SC;Sattar N;Singh C;Wardle J;White SL;Seed PT;Poston L
通讯作者：
Poston L