Hormone replacement therapy in females can decrease the risk of lung cancer: a meta-analysis.
Hormone replacement therapy in females can decrease the risk of lung cancer: a meta-analysis.
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女性激素替代疗法可以降低患肺癌的风险：一项荟萃分析。
DOI：
10.1371/journal.pone.0071236
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Yao Y;Gu X;Zhu J;Yuan D;Song Y
本荟萃分析的目的是确定激素替代疗法（HRT）与女性肺癌风险之间的关系。通过 PubMed、EMBASE 数据库和 Cochrane 图书馆文献检索对截至 2012 年 5 月的出版物进行了审查和获取。使用随机效应模型收集并估计了不同组中患者的详细数量、奇数比 (OR) 和相应的 95% 置信区间 (CI)。二十五项研究进入荟萃分析。参与者总数和肺癌患者总数分别为 656,403 人和 11,442 人。所有 25 项研究的 OR 均为 0.91（95%CI = 0.83 至 0.99），P 值为 0.033。在分层分析中，BMI<25 kg/m2 的患者（OR = 0.65，P = 0.000）和从不吸烟的患者（OR = 0.86，P = 0.042）中也发现使用 HRT 与降低肺癌风险之间呈正相关。然而，人工绝经患者使用HRT会增加肺癌风险，OR = 1.51（P = 0.001）。艾格检验的结果没有显示出任何公共偏见的证据（P = 0.069）。总之，我们对 HRT 和肺癌风险的荟萃分析表明，HRT 的使用与女性肺癌风险降低相关，尤其是 BMI<25 kg/m2 且从不吸烟的女性。
The purpose of the present meta-analysis was to determine the relationship between hormone replacement therapy (HRT) and lung cancer risk in females. Publications were reviewed and obtained through a PubMed, EMBASE database and Cochrane Library literature search up to May, 2012. The detailed numbers of patients in different groups, odd ratios (ORs) and corresponding 95% confidence intervals (CIs) were collected and estimated using a random-effects model. Twenty five studies entered into the meta-analysis. The total number of participates and lung cancer patients was 656,403 and 11,442, respectively. The OR of all 25 studies was 0.91 (95%CI = 0.83 to 0.99) and P value was 0.033. In stratified analyses, the positive association between HRT use and decreased lung cancer risk was also found in the patients with BMI<25 kg/m2 (OR = 0.65, P = 0.000), and never smokers patients (OR = 0.86, P = 0.042). However, HRT use in patients with artificial menopause could increase the lung cancer risk, OR = 1.51(P = 0.001). The result of Egger's test did not show any evidence of publican bias (P = 0.069). In conclusion, our meta-analysis on HRT and lung cancer risk suggests that HRT use is correlated with decreased lung cancer risk in female, especially in female with BMI<25 kg/m2 and never smokers.
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影响因子：
3.1
作者：
Low, AK;Russell, LD;Brown, CA
通讯作者：
Brown, CA
影响因子：
2.3
作者：
Brinton, Louise A.;Schwartz, Lauren;Gierach, Gretchen L.
通讯作者：
Gierach, Gretchen L.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
10.3
作者：
Chlebowski, Rowan T.;Anderson, Garnet L.;Stefanick, Marcia L.
通讯作者：
Stefanick, Marcia L.
影响因子：
7.7
作者：
Kreuzer, M;Gerken, M;Wichmann, HE
通讯作者：
Wichmann, HE