Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease.
Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease.
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DOI：
10.1371/journal.pone.0011422
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发表时间：
2010-07-02
期刊：
影响因子：
3.7
通讯作者：
Jameson JM
中科院分区：
文献类型：
--
作者：
Taylor KR;Mills RE;Costanzo AE;Jameson JM
上皮细胞在屏障组织如皮肤中提供了抵抗损伤和病原体的初始防线;然而，这种平衡在肥胖和代谢疾病中被破坏。皮肤γδ T细胞识别上皮损伤，并释放促进伤口修复的细胞因子和生长因子。我们在此报告，由于STAT 5信号传导改变，高血糖导致皮肤γδ T细胞增殖受损，最终导致表皮中γδ T细胞数量减少一半。克服这种高血糖状态的皮肤γδ T细胞对慢性炎症介质（包括TNFα）引起的上皮细胞损伤无反应。通过体内给予中和TNFα抗体，组织损伤部位的细胞因子和生长因子产生部分恢复。因此，代谢疾病负面影响皮肤γδ T细胞的稳态和功能，使宿主防御机制容易受到损伤和感染。
Epithelial cells provide an initial line of defense against damage and pathogens in barrier tissues such as the skin; however this balance is disrupted in obesity and metabolic disease. Skin γδ T cells recognize epithelial damage, and release cytokines and growth factors that facilitate wound repair. We report here that hyperglycemia results in impaired skin γδ T cell proliferation due to altered STAT5 signaling, ultimately resulting in half the number of γδ T cells populating the epidermis. Skin γδ T cells that overcome this hyperglycemic state are unresponsive to epithelial cell damage due to chronic inflammatory mediators, including TNFα. Cytokine and growth factor production at the site of tissue damage was partially restored by administering neutralizing TNFα antibodies in vivo. Thus, metabolic disease negatively impacts homeostasis and functionality of skin γδ T cells, rendering host defense mechanisms vulnerable to injury and infection.
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DOI：
10.1084/jem.185.9.1573
发表时间：
1997-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cope AP;Liblau RS;Yang XD;Congia M;Laudanna C;Schreiber RD;Probert L;Kollias G;McDevitt HO
通讯作者：
McDevitt HO
影响因子：
3.1
作者：
Daniel, TanJanika;Thobe, Ljoern M.;Schwacha, Martin G.
通讯作者：
Schwacha, Martin G.
影响因子：
27.4
作者：
Clark, J;Vagenas, P;Cope, AP
通讯作者：
Cope, AP
影响因子：
4.3
作者：
Bubici, C;Papa, S;Franzoso, G
通讯作者：
Franzoso, G
影响因子：
4.4
作者：
Burchill, MA;Goetz, CA;Farrar, MA
通讯作者：
Farrar, MA