Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma.
Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma.
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DOI：
10.1002/hed.23600
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发表时间：
2015-03
影响因子：
2.9
通讯作者：
Prince, Mark E. P.
中科院分区：
文献类型：
--
作者：
Chinn, Steven B.;Darr, Owen A.;Owen, John H.;Bellile, Emily;McHugh, Jonathan B.;Spector, Matthew E.;Papagerakis, Silvana M.;Chepeha, Douglas B.;Bradford, Carol R.;Carey, Thomas E.;Prince, Mark E. P.
癌症干细胞（CSC）代表了负责肿瘤生长的细胞亚群。它们在头颈部鳞状细胞癌（HNSCC）的发生和转移中的作用尚不清楚。伤口愈合和正位动物模型用于研究表达CSC表型（CD44high和ALDH+）的细胞，并评估移动性、肿瘤发生和转移。前瞻性收集了40例患者源性原发性HNSCC标本，分析了csc比例与临床变量的比较。与非CSC相比，CSC在体内表现出更快的伤口愈合、更大的肿瘤发生和区域转移。在原发患者肿瘤中，大小和晚期与CSC比例升高相关，但与生存无关。HNSCC CSC介导体内肿瘤发生和局部转移。在原发患者肿瘤中，csc比例与肿瘤大小和分期相关，但与转移扩散或生存无关。单独的CSC负担可能只是理解CSC和转移的一个次要变量。
Cancer stem cells (CSC) represent a subpopulation of cells responsible for tumor growth. Their role in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and metastasis remains uncertain. Wound healing and an orthootopic animal model were used to study cells expressing the CSC phenotype (CD44high and ALDH+) and assess mobility, tumorigenesis and metastasis. A prospective collection of 40 patient-derived primary HNSCC specimens were analyzed for CSC-proportion compared to clinical variables. CSC exhibited significantly faster wound closure and greater tumorigenesis and regional metastasis in-vivo than non-CSC. In primary patient tumors, size and advanced stage were correlated with elevated proportion of CSC, however not with survival. HNSCC CSC mediate tumorigenesis and regional metastasis in-vivo. In primary patient tumors, CSC-proportion was associated with tumor size and stage, but not with metastatic spread or survival. CSC burden alone may only represent a minor variable in understanding CSC and metastasis.
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影响因子：
2.6
作者：
Mayland, MK;Sessions, DG;Lenox, J
通讯作者：
Lenox, J
DOI：
10.1073/pnas.1006732107
发表时间：
2010-10-19
影响因子：
11.1
作者：
Liu, Huiping;Patel, Manishkumar R.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
影响因子：
2.6
作者：
Wang, Steven J.;Wong, Gabriel;de Heer, Anne-Martine;Xia, Weiliang;Bourguignon, Lilly Y. W.
通讯作者：
Bourguignon, Lilly Y. W.
DOI：
10.1016/j.ijrobp.2009.07.001
发表时间：
2009-11-15
影响因子：
7
作者：
Al-Assar, Osama;Muschel, Ruth J.;Brunner, Thomas B.
通讯作者：
Brunner, Thomas B.
DOI：
10.1002/hed.21529
发表时间：
2011-05-01
影响因子：
2.9
作者：
Kuperman, David I.;Auethavekiat, Vorachart;Morgensztern, Daniel
通讯作者：
Morgensztern, Daniel