Predator odor-evoked BOLD activation in the awake rat: modulation by oxytocin and V₁a vasopressin receptor antagonists.
Predator odor-evoked BOLD activation in the awake rat: modulation by oxytocin and V₁a vasopressin receptor antagonists.
复制标题
DOI：
10.1016/j.brainres.2012.11.045
复制
发表时间：
2013-02-04
期刊：
影响因子：
2.9
通讯作者：
Febo M
中科院分区：
文献类型：
--
作者：
Reed MD;Price KE;Archbold J;Moffa A;Febo M
无条件恐惧的调节剂是开发焦虑症治疗的潜在目标。我们使用血氧水平依赖（BOLD）的MRI研究的模式，大脑活动的捕食者气味（猫毛）和令人厌恶的新气味，丁酸（BA），清醒的大鼠。我们进一步测试了气味诱发的BOLD激活是否涉及催产素（OT）和加压素V1a受体。实验前90 min，动物被分为侧脑室注射人工脑脊液（CSF）、OT受体拮抗剂或V1a拮抗剂（各125 ng/10 μ L）的组。BA气味在嗅觉、感觉、记忆和边缘系统区域引起强烈的大脑激活。在这些区域的BOLD激活的幅度大于BA猫毛皮。然而，阻断OT和V1a受体差异调制气味引起的神经活动，特别是在杏仁核。OT和V1a拮抗作用优先调节皮质杏仁核对BA的BOLD反应。而OT和V1a拮抗作用则优先调节杏仁核中央区BOLD对猫毛的反应。这些数据表明，虽然OT受体调节BOLD激活响应一个新的和令人厌恶的气味，如BA，加压素V1a受体施加调节影响的神经反应捕食者气味。
Modulators of unconditioned fear are potential targets for developing treatments for anxiety disorders. We used blood oxygen level dependent (BOLD) MRI to investigate the pattern of brain activity during the presentation of a predator odor (cat fur) and a repulsive novel odor, butyric acid (BA), to awake rats. We further tested whether odor-evoked BOLD activation involved oxytocin (OT) and vasopressin V1a receptors. Animals were subdivided into groups either administered an intracerebroventricular injection of artificial cerebrospinal fluid (CSF), an OT receptor antagonist or a V1a antagonist (125 ng/10 μL each) 90 min before studies. BA odor evoked robust brain activation across olfactory, sensory, memory and limbic regions. The magnitude of BOLD activation across these regions was greater for BA than with cat fur. However, blockade of OT and V1a receptors differentially modulated odor evoked neural activity, particularly in the amygdala. OT and V1a antagonism preferentially modulated BOLD responding to BA in the cortical amygdala. While, OT and V1a antagonisms preferentially modulated BOLD responding to cat fur in the central amygdala. The data suggest that although OT receptors modulate BOLD activation in response to a novel and repulsive odor such as BA, vasopressin V1a receptors exert a modulatory influence on the neural response to a predator odor.
登录
查看更多内容
影响因子：
64.5
作者：
Papes F;Logan DW;Stowers L
通讯作者：
Stowers L
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
4.8
作者：
OSTROWSKI, NL;LOLAIT, SJ;YOUNG, WS
通讯作者：
YOUNG, WS
影响因子：
3.6
作者：
DEWIED, D;GAFFORI, O;DEJONG, W
通讯作者：
DEJONG, W
影响因子：
64.8
作者：
DEWIED, D;GAFFORI, O;DEJONG, W
通讯作者：
DEJONG, W