New insight into adiponectin role in obesity and obesity-related diseases.
New insight into adiponectin role in obesity and obesity-related diseases.
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DOI：
10.1155/2014/658913
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发表时间：
2014
影响因子：
--
通讯作者：
Daniele A
中科院分区：
文献类型：
--
作者：
Nigro E;Scudiero O;Monaco ML;Palmieri A;Mazzarella G;Costagliola C;Bianco A;Daniele A
肥胖是一个主要的健康问题，它强烈增加了各种严重相关并发症的风险，如代谢综合征、心血管疾病、呼吸系统疾病、糖尿病视网膜病变和癌症。脂肪组织是产生生物活性分子的内分泌器官，所述生物活性分子被定义为“脂肪细胞因子”，具有参与能量代谢以及食欲、胰岛素敏感性、炎症、动脉粥样硬化、细胞增殖等的调节的多效性功能的蛋白质激素。在肥胖症中，脂肪积累导致脂肪因子产生失调，这强烈地有助于肥胖相关疾病的发作。在肥胖的治疗和预防方面已经取得了一些进展，但目前的医学疗法即使在顺从的患者中也常常不成功。在脂肪因子中，脂联素在能量代谢、炎症和细胞增殖等多种过程中显示出保护活性。在这篇综述中，我们将重点介绍脂联素及其受体AdipoRs（“脂联素系统”）对肥胖和肥胖相关疾病代谢并发症的保护特性。脂联素表现出抗高血糖、抗动脉粥样硬化和抗炎特性，在开发用于预防和/或治疗肥胖和肥胖相关疾病的疗法方面可能具有重要的临床益处。
Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer. Adipose tissue is an endocrine organ that produces biologically active molecules defined “adipocytokines,” protein hormones with pleiotropic functions involved in the regulation of energy metabolism as well as in appetite, insulin sensitivity, inflammation, atherosclerosis, cell proliferation, and so forth. In obesity, fat accumulation causes dysregulation of adipokine production that strongly contributes to the onset of obesity-related diseases. Several advances have been made in the treatment and prevention of obesity but current medical therapies are often unsuccessful even in compliant patients. Among the adipokines, adiponectin shows protective activity in various processes such as energy metabolism, inflammation, and cell proliferation. In this review, we will focus on the current knowledge regarding the protective properties of adiponectin and its receptors, AdipoRs (“adiponectin system”), on metabolic complications in obesity and obesity-related diseases. Adiponectin, exhibiting antihyperglycemic, antiatherogenic, and anti-inflammatory properties, could have important clinical benefits in terms of development of therapies for the prevention and/or for the treatment of obesity and obesity-related diseases.
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影响因子：
5.6
作者：
Corbi G;Bianco A;Turchiarelli V;Cellurale M;Fatica F;Daniele A;Mazzarella G;Ferrara N
通讯作者：
Ferrara N
影响因子：
5.8
作者：
Christiansen, Tore;Paulsen, Soren K.;Richelsen, Bjorn
通讯作者：
Richelsen, Bjorn
影响因子：
5.4
作者：
Bracale, R.;Labruna, G.;Pasanisi, F.
通讯作者：
Pasanisi, F.
影响因子：
5.8
作者：
Argyropoulos, G;Rankinen, T;Bouchard, C
通讯作者：
Bouchard, C
影响因子：
4
作者：
Almer, Gunter;Saba-Lepek, Matthias;Mangge, Harald
通讯作者：
Mangge, Harald