Satb2 neurons in the parabrachial nucleus mediate taste perception.
Satb2 neurons in the parabrachial nucleus mediate taste perception.
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DOI：
10.1038/s41467-020-20100-8
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发表时间：
2021-01-11
影响因子：
16.6
通讯作者：
Palmiter RD
中科院分区：
文献类型：
--
作者：
Jarvie BC;Chen JY;King HO;Palmiter RD
调节味觉的神经回路已经从外周到皮层被绘制出来，但味觉反应神经元的遗传身份仍然难以捉摸。在这里，我们描述了一个人口的神经元的味觉区的臂旁核，表达转录因子Satb2和项目的味觉相关的地区，包括味觉丘脑和岛叶皮层。使用钙成像在清醒的，自由舔小鼠，我们表明，Satb2神经元响应的五个基本的味觉方式。这些神经元的光遗传激活增强了味觉偏好，而慢性失活则降低了短暂和长期味觉测试中的味觉偏好程度。同时失活Satb2和降钙素基因相关肽神经元的PBN废除反应厌恶的味道。这些数据表明，在臂旁核的味觉信息是由多个群体的神经元，包括Satb2和降钙素基因相关肽神经元。味觉反应神经元的遗传特性尚未确定。作者描述了臂旁核味觉区的神经元，它们表达转录因子Satb 2，投射到味觉相关区域，并调节味觉偏好。
The neural circuitry mediating taste has been mapped out from the periphery to the cortex, but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a population of neurons in the gustatory region of the parabrachial nucleus that express the transcription factor Satb2 and project to taste-associated regions, including the gustatory thalamus and insular cortex. Using calcium imaging in awake, freely licking mice, we show that Satb2 neurons respond to the five basic taste modalities. Optogenetic activation of these neurons enhances taste preferences, whereas chronic inactivation decreases the magnitude of taste preferences in both brief- and long-access taste tests. Simultaneous inactivation of Satb2 and calcitonin gene-related peptide neurons in the PBN abolishes responses to aversive tastes. These data suggest that taste information in the parabrachial nucleus is conveyed by multiple populations of neurons, including both Satb2 and calcitonin gene-related peptide neurons. The genetic identity of taste-responsive neurons has not been determined. The authors describe neurons in the gustatory region of the parabrachial nucleus that express the transcription factor Satb2, project to taste-associated regions, and modulate taste preferences.
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