A concise overview of circadian timing in Drosophila.

A concise overview of circadian timing in Drosophila.
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果蝇昼夜节律的简明概述。

DOI:
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发表时间:
2003
期刊:
Frontiers in Bioscience
影响因子:
--
通讯作者:
R. Costa
R. Costa
中科院分区:
--
文献类型:
--
作者:
M. Zordan;F. Sandrelli;R. Costa

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综述了果蝇昼夜节律的分子机制,特别是主振荡器的核心和光信号输入通路。核心示意性地表示为由两个互锁的转录反馈环组成,主要基于时钟基因周期、无时间、时钟和周期及其产物,其通过与其他伙伴的相互作用产生稳定的24小时内源振荡器。光信号的时钟是多方面的,仍然是许多猜测和研究的主题。在这里,我们审查数据基本上关于时钟蛋白质的作用,永恒的和它的相互作用与色素隐花色素。
The molecular aspects of circadian rhythmicity in Drosophila melanogaster are reviewed, with particular regard to the core of the master oscillator and the light signalling input pathway. The core is schematically represented as consisting of two interlocking transcriptional feedback loops based principally on the clock genes period, timeless, clock and cycle and their products which, through the interaction with other partners, give rise to a stable 24h endogenous oscillator. Light signalling to the clock is multifaceted and is still the subject of much speculation and research. Here we review data essentially regarding the role of the clock protein Timeless and its interaction with the photopigment Cryptochrome.
DOI: 10.1126/science.286.5440.766
发表时间: 1999-10-22
期刊: SCIENCE
影响因子: 56.9
作者:
Glossop, NRJ;Lyons, LC;Hardin, PE
通讯作者: Hardin, PE
DOI: 10.1126/science.280.5369.1599
发表时间: 1998-06-05
期刊: SCIENCE
影响因子: 56.9
作者:
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通讯作者: Kay, SA
DOI: --
发表时间: 1997-08
期刊: Genetics
影响因子: 3.3
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发表时间: 1999-07-23
期刊: SCIENCE
影响因子: 56.9
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通讯作者: Kay, SA