Pretreatment Alterations and Acute Medication Treatment Effects on Brain Task-Related Functional Connectivity in Youth With Bipolar Disorder: A Neuroimaging Randomized Clinical Trial.
Pretreatment Alterations and Acute Medication Treatment Effects on Brain Task-Related Functional Connectivity in Youth With Bipolar Disorder: A Neuroimaging Randomized Clinical Trial.
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DOI：
10.1016/j.jaac.2021.12.015
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发表时间：
2022-08
影响因子：
13.3
通讯作者：
DelBello, Melissa P.
中科院分区：
文献类型：
--
作者：
Li, Wenbin;Lei, Du;Tallman, Maxwell J.;Ai, Yuan;Welge, Jeffrey A.;Blom, Thomas J.;Fleck, David E.;Klein, Christina C.;Patino, Luis R.;Strawn, Jeffrey R.;Gong, Qiyong;Strakowski, Stephen M.;Sweeney, John A.;Adler, Caleb M.;DelBello, Melissa P.
Disruptions in cognition are a clinically significant feature of bipolar disorder (BD). The effects of different treatments on these deficits, and the brain systems that support them, remain to be established. Participants, including 55 healthy individuals and 71 acutely ill youth with mixed/manic BD, performed a continuous performance test to assess vigilance and working memory during task-based fMRI studies. Patients, who were untreated for at least seven days at baseline, and healthy individuals were scanned at pre-treatment baseline and at week one and six. After baseline testing, patients (n = 71) were randomized to six-week double-blind treatment with lithium (n = 26, 1.0–1.2 mEq/L) or quetiapine (n = 45, 400–600 mg). Weighted seed-based connectivity (wSBC) was used to assess regional brain interactions during the attention task compared to the control condition. At baseline, youth with BD showed reduced connectivity between bilateral anterior cingulate cortex (ACC) and both left VLPFC and left insula, and increased connectivity between left VLPFC-left temporal pole, left OFC-right postcentral gyrus and right amygdala-right occipital pole compared to healthy individuals. At week one follow-up, quetiapine but not lithium treatment led to a significant shift of connectivity patterns toward those of the healthy participants. At week six, compared to baseline, there was no difference between treatment conditions, at which time both patient groups showed significant normalization of brain connectivity toward that of healthy individuals. Functional alterations in several brain regions associated with cognitive processing and the integration of cognitive and affective processing were demonstrated in untreated youth with BD prior to treatment. Treatment reduced several of these alterations, with significant effects at week one only in the quetiapine treatment group. We conclude that normalization of functional connectivity might represent a promising biomarker for early target engagement in youth with BD.
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DOI：
10.1038/s41386-021-00989-5
发表时间：
2021-06
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Lei D;Li W;Tallman MJ;Patino LR;McNamara RK;Strawn JR;Klein CC;Nery FG;Fleck DE;Qin K;Ai Y;Yang J;Zhang W;Lui S;Gong Q;Adler CM;Sweeney JA;DelBello MP
通讯作者：
DelBello MP
DOI：
10.1017/s1355617709991019
发表时间：
2010-01
影响因子：
2.6
作者：
Passarotti, Alessandra M.;Sweeney, John A.;Pavuluri, Mani N.
通讯作者：
Pavuluri, Mani N.
影响因子：
4.5
作者：
Hill, SK;Schuepbach, D;Sweeney, JA
通讯作者：
Sweeney, JA
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
17.7
作者：
McTeague, Lisa M.;Rosenberg, Benjamin M.;Etkin, Amit
通讯作者：
Etkin, Amit