Consistency of neuropsychological outcome following damage to prefrontal cortex in the first years of life.
Consistency of neuropsychological outcome following damage to prefrontal cortex in the first years of life.
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DOI：
10.1080/13803390802360526
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发表时间：
2009-02
影响因子：
2.2
通讯作者：
Tranel D
中科院分区：
文献类型：
--
作者：
Anderson SW;Wisnowski JL;Barrash J;Damasio H;Tranel D
在生命的最初几年，前额叶皮层（PFC）受到限制性损伤后神经心理学结果的一致性尚未得到系统的研究。在一个单一的研究案例的基础上，假设核心概况涉及在一般正常的智力能力的背景下发展一个主要的社会缺陷。我们评估了在我们的登记研究中所有在产前至62个月大之间获得局灶性PFC损伤的患者（N=7）的这种特征的一致性。基于详细评估、父母评级和神经心理学测试的临床评级在7名患者中的5名中证实了这一一般特征。社会功能的损害在幼儿期很明显，并持续到成年。在不符合这一特征的两名患者中，一名患者在更广泛的认知缺陷的背景下出现了严重的社交障碍，另一名患者的社交或智力功能没有明显障碍。在儿童期发作的非额叶病变的对照组中未观察到该特征。这些研究结果支持这样一种观点，即在生命的最初几年，PFC的局灶性损伤会导致社会能力的严重损害，尽管结果存在一些变异性。此外，研究结果强调了情绪功能障碍和行为调节不良在这些障碍发展中的重要性。我们的研究概括并证实了Ackerly和Benton在半个多世纪前提出的核心信息。
The consistency of neuropsychological outcome following circumscribed damage to the prefrontal cortex (PFC) in the first years of life has not been systematically investigated. On the basis of a single well-studied case, postulated that the core profile involves development of a primary social defect in the context of generally normal intellectual abilities. We evaluated the consistency of this profile across all patients in our registry who had focal PFC damage acquired between the prenatal period and 62 months of age (N=7). Clinical ratings based on detailed evaluations, parental ratings, and neuropsychological testing confirmed this general profile in 5 of the 7 patients. The impairments of social function were evident in early childhood and persisted into adult life. Of the two patients who did not fit this profile, one had significant social impairment in the context of broader cognitive deficits, and one had no significant impairment of social or intellectual function. The profile was not observed in a comparison group with childhood-onset nonfrontal lesions. These findings support the notion that focal damage to PFC in the first years of life leads to the development of substantial impairment of social competencies, albeit with some variability in outcome. Further, the findings highlight the importance of emotional dysfunction and poor behavior regulation in the development of these impairments. Our studies recapitulate and confirm the core messages set forth by Ackerly and Benton more than a half-century ago.
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影响因子：
14.5
作者：
Tranel, D;Damasio, H;Bechara, A
通讯作者：
Bechara, A
影响因子：
--
作者：
DAMASIO, H;FRANK, R
通讯作者：
FRANK, R
影响因子：
1.5
作者：
BENTON, A
通讯作者：
BENTON, A
DOI：
10.1017/s1355617704102129
发表时间：
2004-05-01
影响因子：
2.6
作者：
Levin, HS;Zhang, LF;Hunter, JV
通讯作者：
Hunter, JV
DOI：
10.1176/appi.neuropsych.18.1.21
发表时间：
2006-12-01
影响因子：
2.9
作者：
Max, JE;Levin, HS;Dennis, M
通讯作者：
Dennis, M