Direct Aqueous-Phase Synthesis of Sub-10 nm "Luminous Pearls" with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence.
Direct Aqueous-Phase Synthesis of Sub-10 nm "Luminous Pearls" with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence.
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DOI：
10.1021/jacs.5b00872
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发表时间：
2015-04-29
影响因子：
15
通讯作者：
Han G
中科院分区：
文献类型：
--
作者：
Li Z;Zhang Y;Wu X;Huang L;Li D;Fan W;Han G
近红外（NIR）持久发光纳米粒子（PLNPs）具有独特的近红外发光特性，在化学和生物学领域有着广泛的应用前景。在此，我们报告了第一个直接的水相化学合成路线的近红外PLNP，并提出其增强的体内可再生近红外PL。我们的方法导致单分散PLNP小至约。8nm。这种亚10 nm的纳米晶体易于分散和功能化，并且可以在水溶液和细胞培养基中形成稳定的胶体溶液用于生物应用。在生物组织可穿透的红光激发下，我们发现这种纳米晶体在体外和体内具有上级可再生PL光致发光，与现有方法制备的较大对应物相比。我们相信，这种无固态反应的化学方法克服了目前PLNP发展的关键障碍，从而为这些先进的微型“夜明珠”在光子学和生物光子学中的广泛应用铺平了道路。
Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs), possessing unique NIR PL properties, have recently emerged as important materials for a wide variety of applications in chemistry and biology, for which they must endure high-temperature solid-state annealing reactions and subsequent complicated physical post-treatments. Herein, we report on a first direct aqueous-phase chemical synthesis route to NIR PLNPs and present their enhanced in vivo renewable NIR PL. Our method leads to monodisperse PLNPs as small as ca. 8 nm. Such sub-10 nm nanocrystals are readily dispersed and functionalized, and can form stable colloidal solutions in aqueous solution and cell culture medium for biological applications. Under biotissue-penetrable red-light excitation, we found that such nanocrystals possess superior renewable PL photoluminescence in vitro and in vivo compared to their larger counterparts currently made by existing methods. We believe that this solid-state-reaction-free chemical approach overcomes the current key roadblock in regard to PLNP development, and thus will pave the way to broad use of these advanced miniature “luminous pearls” in photonics and biophotonics.
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影响因子：
4.6
作者：
Liu, Feng;Yan, Wuzhao;Chuang, Yen-Jun;Zhen, Zipeng;Xie, Jin;Pan, Zhengwei
通讯作者：
Pan, Zhengwei
DOI：
10.3390/ma6072789
发表时间：
2013-07-12
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Van den Eeckhout K;Poelman D;Smet PF
通讯作者：
Smet PF
影响因子：
16.6
作者：
Wang, Feng;Wang, Juan;Liu, Xiaogang
通讯作者：
Liu, Xiaogang
影响因子：
15
作者：
Testino, Andrea;Bellobono, Ignazio Renato;Morazzoni, Franca
通讯作者：
Morazzoni, Franca
水热均相共沉淀法合成花状Sr2MgSi2O7 : Eu2 , Dy3荧光粉及其发光性能
影响因子：
--
作者：
Zheng, Mingtao;Chen, Xiaobo;Liu, Xiaotang
通讯作者：
Liu, Xiaotang