The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes.
The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes.
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DOI：
10.1055/s-0031-1275516
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发表时间：
2011-05
影响因子：
2.7
通讯作者：
Hay WW Jr
中科院分区：
文献类型：
--
作者：
Thorn SR;Rozance PJ;Brown LD;Hay WW Jr
The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in response to exposure to reduced nutrient supply. These adaptations provide survival value for the fetus by enhancing the capacity of the fetus to take up and use nutrients, thereby reducing the need for nutrient supply. Each organ and tissue in the fetus adapts differently, with the brain showing the greatest capacity for maintaining nutrient supply and growth. Such adaptations, if persistent, also have the potential in later life to promote nutrient uptake and storage, which directly lead to complications of obesity, insulin resistance, reduced insulin production, and type 2 diabetes.
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