Prefrontal-hippocampal pathways underlying inhibitory control over memory.
Prefrontal-hippocampal pathways underlying inhibitory control over memory.
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DOI：
10.1016/j.nlm.2015.11.008
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发表时间：
2016-10
影响因子：
2.7
通讯作者：
Barbas H
中科院分区：
文献类型：
--
作者：
Anderson MC;Bunce JG;Barbas H
前额叶皮层的一个关键功能是支持对行为的抑制性控制。人们普遍认为，这种功能也延伸到停止认知过程。与此一致的是，越来越多的证据证实了右侧前额叶皮层在认知控制中的作用：检索抑制。检索抑制指的是当一个记忆提示出现时，有意识地停止检索过程的能力。功能成像数据表明，检索抑制涉及背外侧前额叶皮层自上而下的海马活动调节，但支持这种抑制调节的解剖学途径尚不清楚。在这里，我们将通过功能成像观察到的检索抑制的关键发现与在非人类灵长类动物中观察到的相关解剖通路的详细考虑结合起来，弥合了这一差距。选择性地关注前扣带皮层的潜在作用，我们提出了两个关于抑制过程中外侧前额叶皮层和内侧颞叶之间相互作用的通路及其细胞靶点的假设：内鼻门控假说和通过团结核进行的丘脑-海马调节假说。我们假设，虽然内嗅门控处于主动停止检索的位置，但丘脑-海马调节可能会反应性地中断正在进行的检索行为。分离出构成检索抑制的通路有可能促进我们对一系列以持续侵入性思想为特征的精神疾病的理解。更广泛地说，检索抑制的解剖学解释将为理解对认知的抑制控制提供一个关键的模型系统。
A key function of the prefrontal cortex is to support inhibitory control over behavior. It is widely believed that this function extends to stopping cognitive processes as well. Consistent with this, mounting evidence establishes the role of the right lateral prefrontal cortex in a clear case of cognitive control: retrieval suppression. Retrieval suppression refers to the ability to intentionally stop the retrieval process that arises when a reminder to a memory appears. Functional imaging data indicates that retrieval suppression involves top-down modulation of hippocampal activity by the dorsolateral prefrontal cortex, but the anatomical pathways supporting this inhibitory modulation remain unclear. Here we bridge this gap by integrating key findings about retrieval suppression observed through functional imaging with a detailed consideration of relevant anatomical pathways observed in non-human primates. Focusing selectively on the potential role of the anterior cingulate cortex, we develop two hypotheses about the pathways mediating interactions between lateral prefrontal cortex and the medial temporal lobes during suppression, and their cellular targets: the entorhinal gating hypothesis, and thalamo-hippocampal modulation via the nucleus reuniens. We hypothesize that whereas entorhinal gating is well situated to stop retrieval proactively, thalamo-hippocampal modulation may interrupt an ongoing act of retrieval reactively. Isolating the pathways that underlie retrieval suppression holds the potential to advance our understanding of a range of psychiatric disorders characterized by persistent intrusive thoughts. More broadly, an anatomical account of retrieval suppression would provide a key model system for understanding inhibitory control over cognition.
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影响因子：
64.8
作者：
Anderson, MC;Green, C
通讯作者：
Green, C
影响因子：
3.5
作者：
Barbas, H;Blatt, GJ
通讯作者：
Blatt, GJ
影响因子：
19.9
作者：
Anderson, Michael C.;Hanslmayr, Simon
通讯作者：
Hanslmayr, Simon
影响因子：
3.4
作者：
Apergis-Schoute, John;Pinto, Aline;Pare, Denis
通讯作者：
Pare, Denis
影响因子：
2.5
作者：
Buckmaster, PS;Alonso, A;Amaral, DG
通讯作者：
Amaral, DG