Portable mass spectrometry system: instrumentation, applications, and path to 'omics analysis.

Portable mass spectrometry system: instrumentation, applications, and path to 'omics analysis.
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DOI:
10.1002/pmic.202200112
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发表时间:
2022-12
期刊:
影响因子:
3.4
通讯作者:
--
中科院分区:
生物学3区
文献类型:
--
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质谱(MS)是一种信息丰富的分析技术,在各种组学研究中起着关键作用。标准质谱仪体积庞大,在高真空下操作,这阻碍了它们在更广泛的社区和现场应用中的应用。开发便携式质谱仪可以显著扩大质谱分析的应用范围和用户群体。本文综述了便携式质谱仪的基本原理和主要组成部分,包括电离源、质谱仪、检测器和真空系统的最新进展。此外,还讨论了便携式质谱仪的主要应用领域。最后,对便携式质谱仪的进一步发展及其在组学分析中的潜在优势进行了展望。
Mass spectrometry (MS) is an information rich analytical technique and plays a key role in various ‘omics studies. Standard mass spectrometers are bulky and operate at high vacuum, which hinder their adoption by the broader community and utility in field applications. Developing portable mass spectrometers can significantly expand the application scope and user groups of MS analysis. This review discusses the basics and recent advancements in the development of key components of portable mass spectrometers including ionization source, mass analyzer, detector, and vacuum system. Further, major areas where portable mass spectrometers are applied are also discussed. Finally, a perspective on the further development of portable mass spectrometers including the potential benefits for ‘omics analysis is provided.
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