Individual differences in GABA content are reliable but are not uniform across the human cortex.
Individual differences in GABA content are reliable but are not uniform across the human cortex.
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GABA含量的个体差异是可靠的，但在人类皮质中并不统一。
DOI：
10.1016/j.neuroimage.2016.06.007
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发表时间：
2016-10-01
期刊：
影响因子：
5.7
通讯作者：
Ivry RB
中科院分区：
文献类型：
--
作者：
Greenhouse I;Noah S;Maddock RJ;Ivry RB
1H 磁共振波谱 (MRS) 提供了测量 γ-氨基丁酸 (GABA) 的强大工具，GABA 是人脑中的主要抑制性神经递质。我们询问 MRS 对 GABA 的估计的个体差异是否在整个皮层中是一致的，还是在不同区域之间存在差异。在两个疗程中，测量了 28 名健康个体的外侧前额叶、感觉运动、背侧前运动和枕叶皮质的静息 GABA 浓度。每个区域内的 GABA 估计值在几周内保持稳定，变异系数较低。尽管具有这种稳定性，但 GABA 估计值在区域之间并不相关。相比之下，每体积脑组织的百分比（一种对照测量）在三个前部区域之间相关。这些结果提供了个体差异的解剖学测量和神经化学测量之间有趣的分离。不同的解剖结构和 GABA 浓度模式对于理解健康和疾病状态下大脑分子拓扑的区域变化具有重要意义。
1H magnetic resonance spectroscopy (MRS) provides a powerful tool to measure gamma-aminobutyric acid (GABA), the principle inhibitory neurotransmitter in the human brain. We asked whether individual differences in MRS estimates of GABA are uniform across the cortex or vary between regions. In two sessions, resting GABA concentrations in the lateral prefrontal, sensorimotor, dorsal premotor, and occipital cortices were measured in twenty-eight healthy individuals. GABA estimates within each region were stable across weeks, with low coefficients of variation. Despite this stability, the GABA estimates were not correlated between regions. In contrast, the percentage of brain tissue per volume, a control measure, was correlated between the three anterior regions. These results provide an interesting dissociation between an anatomical measure of individual differences and a neurochemical measure. The different patterns of anatomy and GABA concentrations have implications for understanding regional variation in the molecular topography of the brain in health and disease.
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影响因子：
4.2
作者：
Blicher JU;Near J;Næss-Schmidt E;Stagg CJ;Johansen-Berg H;Nielsen JF;Østergaard L;Ho YC
通讯作者：
Ho YC
影响因子：
14.9
作者：
Illingworth RS;Gruenewald-Schneider U;De Sousa D;Webb S;Merusi C;Kerr AR;James KD;Smith C;Walker R;Andrews R;Bird AP
通讯作者：
Bird AP
影响因子：
4.7
作者：
Grachev, ID;Swarnkar, A;Apkarian, AV
通讯作者：
Apkarian, AV
DOI：
10.1016/j.cub.2010.09.003
发表时间：
2010-10-12
期刊：
Current biology : CB
影响因子：
--
作者：
Boy F;Evans CJ;Edden RA;Singh KD;Husain M;Sumner P
通讯作者：
Sumner P
影响因子：
5.7
作者：
Bergmann, Johanna;Pilatus, Ulrich;Pearson, Joel
通讯作者：
Pearson, Joel