Association of cardiovascular health and epigenetic age acceleration.
Association of cardiovascular health and epigenetic age acceleration.
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DOI：
10.1186/s13148-021-01028-2
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发表时间：
2021-02-25
影响因子：
5.7
通讯作者：
Hou L
中科院分区：
文献类型：
--
作者：
Pottinger TD;Khan SS;Zheng Y;Zhang W;Tindle HA;Allison M;Wells G;Shadyab AH;Nassir R;Martin LW;Manson JE;Lloyd-Jones DM;Greenland P;Baccarelli AA;Whitsel EA;Hou L
心血管健康(CVH)已被美国心脏协会(AHA)定义为存在“生活简单7”的理想生活方式和临床因素。众所周知，CVH可以预测长寿和免于心血管疾病，心血管疾病是美国女性的主要死亡原因。衰老的DNA甲基化标志物已被聚集到一个综合的表观遗传年龄评分中，该评分与心血管疾病的发病率和死亡率有关。然而，尚不清楚不良的CVH是否与表观遗传年龄的DNA甲基化标记物测量的衰老加速有关。我们对1993至1998年间招募的妇女健康倡议队列中登记的不同种族的绝经后妇女进行了横断面分析。表观遗传年龄加速(EAA)是使用参与者子集上的DNA甲基化数据以及已发表的内在和外在EAA的Horvath和Hannum方法计算的。CVH是使用CVH的AHA测量来计算的，CVH的得分为7分。我们使用线性回归模型检验了CVH评分和EAA之间的关系，调整了自我报告的种族/民族和教育程度。在分析的2,170名参与者中，50%是白人，平均年龄为(7岁)。更高或更有利的脑血管出血评分与较低的外源性EAA(每1分低6个月年龄，p <； 0.0001)和较低的内在EAA(每1分高3个月年龄，p <； 0.028)相关。这些横断面观察提示了一种可能的机制，即理想的CVH与更长寿有关。
Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States. DNA methylation markers of aging have been aggregated into a composite epigenetic age score, which is associated with cardiovascular morbidity and mortality. However, it is unknown whether poor CVH is associated with acceleration of aging as measured by DNA methylation markers in epigenetic age. We performed a cross-sectional analysis of racially/ethnically diverse post-menopausal women enrolled in the Women’s Health Initiative cohort recruited between 1993 and 1998. Epigenetic age acceleration (EAA) was calculated using DNA methylation data on a subset of participants and the published Horvath and Hannum methods for intrinsic and extrinsic EAA. CVH was calculated using the AHA measures of CVH contributing to a 7-point score. We examined the association between CVH score and EAA using linear regression modeling adjusting for self-reported race/ethnicity and education. Among the 2,170 participants analyzed, 50% were white and mean age was 64 (7 SD) years. Higher or more favorable CVH scores were associated with lower extrinsic EAA (~ 6 months younger age per 1 point higher CVH score, p < 0.0001), and lower intrinsic EAA (3 months younger age per 1 point higher CVH score, p < 0.028). These cross-sectional observations suggest a possible mechanism by which ideal CVH is associated with greater longevity.
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影响因子：
4.4
作者：
Bibikova, Marina;Barnes, Bret;Shen, Richard
通讯作者：
Shen, Richard
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
5.7
作者：
Nevalainen T;Kananen L;Marttila S;Jylhävä J;Mononen N;Kähönen M;Raitakari OT;Hervonen A;Jylhä M;Lehtimäki T;Hurme M
通讯作者：
Hurme M
影响因子：
5.7
作者：
Nannini, Drew R.;Joyce, Brian T.;Hou, Lifang
通讯作者：
Hou, Lifang
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S