Marrow fat metabolism is linked to the systemic energy metabolism.
Marrow fat metabolism is linked to the systemic energy metabolism.
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DOI：
10.1016/j.bone.2011.06.032
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发表时间：
2012-02
期刊：
影响因子：
4.1
通讯作者：
Lecka-Czernik, Beata
中科院分区：
文献类型：
--
作者：
Lecka-Czernik, Beata
对骨在能量代谢的系统调节中的作用的理解的最新进展表明，骨髓细胞、脂肪细胞和成骨细胞参与了这一过程。骨髓脂肪细胞储存大量的脂肪并产生脂肪因子、瘦素和脂联素，它们在调节能量代谢中的作用是众所周知的，而成骨细胞产生骨钙素，骨钙素是一种骨特异性激素，具有调节胰腺中胰岛素产生和脂肪组织中脂联素产生的潜力。成骨细胞和骨髓脂肪细胞都表达胰岛素受体，并以一种将骨与能量代谢系统紧密联系起来的方式对胰岛素增敏性抗糖尿病TZDs作出反应。骨髓脂肪的代谢特征类似于白色脂肪和棕色脂肪，这反映在其获得包括维持骨微环境在内的不同功能的可塑性。骨髓脂肪通过改变体积和代谢活性来响应能量代谢状态的生理和病理变化。这篇综述总结了骨髓脂肪代谢功能的现有信息，并提供了一个假设，即这种脂肪库可能会获得多种角色，这取决于局部和全身的需求。这些功能可能包括在骨能量维持和内分泌活动中的作用，以在骨重建和骨愈合期间服务于骨生成。
Recent advances in understanding the role of bone in the systemic regulation of energy metabolism indicate that bone marrow cells, adipocytes and osteoblasts, are involved in this process. Marrow adipocytes store significant quantities of fat and produce adipokines, leptin and adiponectin, which are known for their role in the regulation of energy metabolism, whereas osteoblasts produce osteocalcin, a bone-specific hormone that has a potential to regulate insulin production in the pancreas and adiponectin production in fat tissue. Both osteoblasts and marrow adipocytes express insulin receptor and respond to insulin-sensitizing anti-diabetic TZDs in a manner, which tightly links bone with the energy metabolism system. Metabolic profile of marrow fat resembles that of both, white and brown fat, which is reflected by its plasticity in acquiring different functions including maintenance of bone micro-environment. Marrow fat responds to physiologic and pathologic changes in energy metabolism status by changing volume and metabolic activity. This review summarizes available information on the metabolic function of marrow fat and provides hypothesis that this fat depot may acquire multiple roles depending on the local and perhaps systemic demands. These functions may include a role in bone energy maintenance and endocrine activities to serve osteogenesis during bone remodeling and bone healing.
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影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
影响因子：
3.9
作者：
Gasparrini, Marco;Rivas, Daniel;Duque, Gustavo
通讯作者：
Duque, Gustavo
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
4.8
作者：
Fretz, Jackie A.;Nelson, Tracy;Horowitz, Mark C.
通讯作者：
Horowitz, Mark C.