Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors.

Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors.
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DOI:
10.1016/j.semcdb.2016.03.012
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发表时间:
2016-07
影响因子:
7.3
通讯作者:
Devenport, Danelle
Devenport, Danelle
中科院分区:
生物学2区
文献类型:
--
作者:
Devenport, Danelle

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细胞集体定向和排列其行为的能力在多细胞生物体中对于单向纤毛跳动、集体细胞运动、定向细胞分裂和不对称细胞命运特化是必不可少的。平面细胞极性通路通过与调节细胞骨架动力学和细胞间信号传导的下游通路交叉来协调大量多样的集体细胞行为。平面极性通路如何将方向性信号转化为极化细胞行为是本文的重点。
The ability of cells to collectively orient and align their behaviors is essential in multicellular organisms for unidirectional cilia beating, collective cell movements, oriented cell divisions, and asymmetric cell fate specification. The planar cell polarity pathway coordinates a vast and diverse array of collective cell behaviors by intersecting with downstream pathways that regulate cytoskeletal dynamics and intercellular signaling. How the planar polarity pathway translates directional cues to produce polarized cell behaviors is the focus of this review.
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