Metabolic abnormalities in adolescents with polycystic ovary syndrome in south China.
Metabolic abnormalities in adolescents with polycystic ovary syndrome in south China.
复制标题
华南地区青少年多囊卵巢综合征代谢异常情况
DOI：
10.1186/1477-7827-8-142
复制
发表时间：
2010-11-17
期刊：
影响因子：
--
通讯作者：
Yang D
中科院分区：
文献类型：
--
作者：
Huang J;Ni R;Chen X;Huang L;Mo Y;Yang D
背景：成人多囊卵巢综合征（PCOS）可伴有多种代谢异常。然而，对青少年人群的研究仍然有限，这些结果似乎差异很大。本研究旨在探讨华南地区青少年多囊卵巢综合征（PCOS）的代谢异常及其潜在危险因素。方法对128例PCOS青少年及其年龄、bmi相匹配的对照组进行了人体测量和生化指标评价。结果PCOS青少年糖尿病前期、胰岛素抵抗、高胰岛素血症、血脂异常和代谢综合征患病率分别为11.7%、46.9%、29.7%、22.7%和4.7%。BMI < 85的PCOS患者有糖尿病前期、胰岛素抵抗、高胰岛素血症、血脂异常和代谢综合征的比例分别为16.3%、74.4%、67.4%、39.5%和14%，BMI < 85的PCOS患者有糖尿病前期、胰岛素抵抗、高胰岛素血症、血脂异常和代谢综合征的比例分别为9.4%、32.9%、10.6%、14.1%和0%。结论华南地区多囊卵巢综合征青少年代谢异常高于年龄和bmi匹配的非多囊卵巢综合征青少年。肥胖可加重PCOS青少年的胰岛素抵抗、高胰岛素血症和代谢综合征。
BackgroundAdults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential risk factors contributed to these health risks.MethodsAnthropometric measurements and biochemical parameters were evaluated in 128 adolescents with PCOS and their age- and BMI-matched controls.ResultsThe prevalence of pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome in adolescents with PCOS was 11.7%, 46.9%, 29.7%, 22.7% and 4.7%, respectively. 16.3%, 74.4%, 67.4%, 39.5% and 14% of the PCOS subjects with BMI > 85th had pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome, whereas 9.4%, 32.9%, 10.6%, 14.1% and 0% of the PCOS subjects with BMI < 85th had such disturbances.ConclusionsAdolescents with PCOS in South China had more metabolic abnormalities than their age- and BMI-matched non-PCOS counterparts. Obesity could worsen insulin resistance, hyperinsulinemia and metabolic syndrome in PCOS adolescents.
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DOI：
10.1111/j.1471-0528.2006.01008.x
发表时间：
2006-10-01
影响因子：
5.8
作者：
Broekmans, F. J.;Knauff, E. A. H.;Fauser, B. C. J. M.
通讯作者：
Fauser, B. C. J. M.
影响因子：
16.2
作者：
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影响因子：
6.7
作者：
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通讯作者：
Azziz, R
影响因子：
6.1
作者：
Chen, Xiaoli;Ni, Renmin;Yang, Dongzi
通讯作者：
Yang, Dongzi
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.