Vascular endothelium - Gatekeeper of vessel health.
Vascular endothelium - Gatekeeper of vessel health.
复制标题
血管内皮 - 船只健康的看门人。
DOI:
10.1016/j.atherosclerosis.2016.03.007
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发表时间:
2016-05
期刊:
影响因子:
5.3
通讯作者:
Redmond EM
中科院分区:
文献类型:
--
作者:
Cahill PA;Redmond EM
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the artery wall are believed of primary importance in the pathogenesis of vascular disease/atherosclerosis. The endothelium responds to humoral, neural and especially hemodynamic stimuli and regulates platelet function, inflammatory responses, vascular smooth muscle cell growth and migration, in addition to modulating vascular tone by synthesizing and releasing vasoactive substances. Compromised endothelial function contributes to the pathogenesis of cardiovascular disease; endothelial ‘dysfunction’ is associated with risk factors, correlates with disease progression, and predicts cardiovascular events. Therapies for atherosclerosis have been developed, therefore, that are directed towards improving endothelial function.
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