Vascular endothelium - Gatekeeper of vessel health.

Vascular endothelium - Gatekeeper of vessel health.
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血管内皮 - 船只健康的看门人。

DOI:
10.1016/j.atherosclerosis.2016.03.007
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发表时间:
2016-05
期刊:
影响因子:
5.3
通讯作者:
Redmond EM
Redmond EM
中科院分区:
医学2区
文献类型:
--
作者:
Cahill PA;Redmond EM

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血管内皮是血流和血管壁之间的界面。动脉壁的这种单细胞层的变化被认为在血管疾病/动脉粥样硬化的发病机制中是最重要的。内皮对体液、神经和特别是血液动力学刺激作出反应,并且除了通过合成和释放血管活性物质来调节血管张力之外,还调节血小板功能、炎症反应、血管平滑肌细胞生长和迁移。内皮功能受损有助于心血管疾病的发病机制;内皮“功能障碍”与危险因素相关,与疾病进展相关,并预测心血管事件。因此,已经开发了针对改善内皮功能的动脉粥样硬化疗法。
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the artery wall are believed of primary importance in the pathogenesis of vascular disease/atherosclerosis. The endothelium responds to humoral, neural and especially hemodynamic stimuli and regulates platelet function, inflammatory responses, vascular smooth muscle cell growth and migration, in addition to modulating vascular tone by synthesizing and releasing vasoactive substances. Compromised endothelial function contributes to the pathogenesis of cardiovascular disease; endothelial ‘dysfunction’ is associated with risk factors, correlates with disease progression, and predicts cardiovascular events. Therapies for atherosclerosis have been developed, therefore, that are directed towards improving endothelial function.
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