The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review.
The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review.
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阿尔茨海默病的海马保留亚型在神经病理学和体内tau正电子发射断层扫描中评估：一项系统综述。
DOI：
10.1186/s40478-022-01471-z
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发表时间：
2022-11-14
影响因子：
7.1
通讯作者：
中科院分区：
文献类型：
--
作者：
神经病理学和神经影像学研究已经确定了阿尔茨海默病（AD）的几种亚型：海马保留型AD、典型AD和边缘系统主导型AD。一个尚未解决的问题是海马保留AD病例是否可以在联合皮质中出现神经元缠结（NFT），而完全保留海马。为了解决这个问题，我们对tau正电子发射断层扫描（PET）数据进行了系统回顾和原始分析。我们检索了EMBASE、PubMed和Web of Science数据库，直至2022年10月。我们还在tau PET上实施了几种AD亚型分型方法，以识别海马保留的AD病例。我们的研究结果表明，七个审查的神经病理学研究包括Braak IV期或更高的情况下，因此，不能确定海马保留的情况下，NFT完全保留海马。相比之下，tau PET确实识别了在联合皮质中具有示踪剂保留的AD参与者，而完全保留了海马。我们的结论是，tau PET可以识别海马保留AD病例与NFT完全保留海马。基于积累的数据，我们提出了两种可能的tau扩散途径：（1）早期累及经内嗅皮质，随后累及边缘区和联合皮质的典型途径，以及（2）影响联合皮质的不太常见的途径，在疾病的末期观察到边缘受累或根本不受累。在线版本包含补充材料，可通过10.1186/s40478 - 022 - 01471-z获得。
Neuropathology and neuroimaging studies have identified several subtypes of Alzheimer’s disease (AD): hippocampal sparing AD, typical AD, and limbic predominant AD. An unresolved question is whether hippocampal sparing AD cases can present with neurofibrillary tangles (NFT) in association cortices while completely sparing the hippocampus. To address that question, we conducted a systematic review and performed original analyses on tau positron emission tomography (PET) data. We searched EMBASE, PubMed, and Web of Science databases until October 2022. We also implemented several methods for AD subtyping on tau PET to identify hippocampal sparing AD cases. Our findings show that seven out of the eight reviewed neuropathologic studies included cases at Braak stages IV or higher and therefore, could not identify hippocampal sparing cases with NFT completely sparing the hippocampus. In contrast, tau PET did identify AD participants with tracer retention in the association cortex while completely sparing the hippocampus. We conclude that tau PET can identify hippocampal sparing AD cases with NFT completely sparing the hippocampus. Based on the accumulating data, we suggest two possible pathways of tau spread: (1) a canonical pathway with early involvement of transentorhinal cortex and subsequent involvement of limbic regions and association cortices, and (2) a less common pathway that affects association cortices with limbic involvement observed at end stages of the disease or not at all. The online version contains supplementary material available at 10.1186/s40478-022-01471-z.
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影响因子：
4.2
作者：
Coughlin DG;Phillips JS;Roll E;Peterson C;Lobrovich R;Rascovsky K;Ungrady M;Wolk DA;Das S;Weintraub D;Lee EB;Trojanowski JQ;Shaw LM;Vaishnavi S;Siderowf A;Nasrallah IM;Irwin DJ;McMillan CT;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
DOI：
10.1016/s1474-4422(20)30440-3
发表时间：
2021-03
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graff-Radford J;Yong KXX;Apostolova LG;Bouwman FH;Carrillo M;Dickerson BC;Rabinovici GD;Schott JM;Jones DT;Murray ME
通讯作者：
Murray ME
影响因子：
4
作者：
Cupidi, Chiara;Capobianco, Raffaella;Giaccone, Giorgio
通讯作者：
Giaccone, Giorgio
影响因子：
4.1
作者：
Gungor, Ipek;Sarro, Lidia;Kantarci, Kejal
通讯作者：
Kantarci, Kejal
影响因子：
3.5
作者：
Ferreira, Daniel;Hansson, Oskar;Westman, Eric
通讯作者：
Westman, Eric