Multimodal in vivo and postmortem assessments of tau in Lewy body disorders.
Multimodal in vivo and postmortem assessments of tau in Lewy body disorders.
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DOI：
10.1016/j.neurobiolaging.2020.08.003
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发表时间：
2020-12
影响因子：
4.2
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Coughlin DG;Phillips JS;Roll E;Peterson C;Lobrovich R;Rascovsky K;Ungrady M;Wolk DA;Das S;Weintraub D;Lee EB;Trojanowski JQ;Shaw LM;Vaishnavi S;Siderowf A;Nasrallah IM;Irwin DJ;McMillan CT;Alzheimer’s Disease Neuroimaging Initiative
我们比较了20名路易体疾病（LBD）患者、12名淀粉样蛋白PET扫描呈阳性的匹配阿尔茨海默病患者（AD+Aβ）和15名淀粉样蛋白PET扫描呈阴性的健康对照者（HC-Aβ）中18 F-氟陶西匹的局部保留以及LBD中保留与尸检时CSF tau、认知能力和神经病理学tau之间的关联。使用已确立的Aβ42临界值192 pg/ml对LBD队列进行分层，以富集可能具有tau病理学的组（LBD+Aβ=11，LBD-Aβ=9）。LBD+AB组在5个（主要是颞顶叶）皮质区域中的18 F-flortaucipir保留率高于HC-Aβ，而LBD-A β在一个皮质区域中升高，内侧颞区除外。更高的保留与更高的CSF总tau水平（p=0.04）、更差的领域特异性认知表现（p=0.02-0.04）和相应区域中更严重的神经病理性tau相关。我们的结论是，虽然18F-flotaucipir保留在LBD是健康对照和AD之间的中间，保留与认知障碍，CSF总tau蛋白和神经病理性tau蛋白。未来需要在更大的尸检验证队列中开展工作，以定义LBD特异性tau生物标志物谱。
We compared the regional retention of 18F-flortaucipir in twenty patients with Lewy Body disorders (LBD), twelve matched Alzheimer’s disease patients with positive amyloid PET scans (AD+Aβ), and fifteen healthy-controls with negative amyloid PET scans (HC-Aβ) and the association in LBD between retention and CSF tau, cognitive performance, and neuropathological tau at autopsy. The LBD cohort was stratified using an established Aβ42 cut-off of 192pg/ml to enrich for groups likely harboring tau pathology (LBD+Aβ=11, LBD-Aβ=9). 18F-flortaucipir retention was higher in LBD+AB than HC-Aβ in five, largely temporal-parietal, cortical regions whereas LBD-Aβ had elevations in one cortical region with sparing of medial temporal areas. Higher retention was associated with higher CSF total-tau levels (p=0.04), poorer domain-specific cognitive performance (p=0.02-0.04), and greater severity of neuropathological tau in corresponding regions. We conclude that while 18F-flortaucipir retention in LBD is intermediate between healthy-controls and AD, retention relates to cognitive impairment, CSF total-tau, and neuropathological tau. Future work in larger autopsy-validated cohorts are needed to define LBD-specific tau biomarker profiles.
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影响因子：
48
作者：
Irwin, David;Grossman, Murray;Weintraub, Daniel;Hurtig, Howard I.;Duda, John E.;Xie, Sharon X.;Lee, Edward B.;Van Deerlin, Vivianna M.;Lopez, Oscar L.;Kofler, Julia K.;Nelson, Peter T.;Jicha, Gregory A.;Woltjer, Randy;Quinn, Joseph F.;Kaye, Jeffery;Leverenz, James B.;Tsuang, Debby;Longfellow, Katelan;Yearout, Dora;Kukull, Walter;Keene, C. Dirk;Montine, Thomas J.;Zabetian, Cyrus P.;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.
DOI：
10.1016/j.jalz.2015.05.001
发表时间：
2015-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jagust WJ;Landau SM;Koeppe RA;Reiman EM;Chen K;Mathis CA;Price JC;Foster NL;Wang AY
通讯作者：
Wang AY
影响因子：
12.7
作者：
Iseki, E;Togo, T;Kosaka, K
通讯作者：
Kosaka, K
影响因子：
8.6
作者：
Hansen, Allan K.;Damholdt, Malene Flensborg;Borghammer, Per
通讯作者：
Borghammer, Per
影响因子：
3.2
作者：
Irwin, David J.;Byrne, Matthew D.;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.