Differential expression of respiratory long-term facilitation among inbred rat strains.
Differential expression of respiratory long-term facilitation among inbred rat strains.
复制标题
近交系大鼠品系中呼吸长期易化的差异表达。
DOI：
10.1016/j.resp.2009.12.008
复制
发表时间：
2010-03-31
影响因子：
2.3
通讯作者：
Mitchell, G. S.
中科院分区：
文献类型：
--
作者：
Baker-Herman, T. L.;Bavis, R. W.;Dahlberg, J. M.;Mitchell, A. Z.;Wilkerson, J. E. R.;Golder, F. J.;MacFarlane, P. M.;Watters, J. J.;Behan, M.;Mitchell, G. S.
我们检验了以下假设：1）急性间歇性缺氧（AIH）后的长时程易化（LTF）在三种近交系大鼠（Fischer 344（F344）、Brown Norway（BN）和刘易斯大鼠）中存在差异; 2）膈LTF（pLTF）重要基因的腹侧颈髓水平与pLTF幅度相关。刘易斯和F344，但不是BN大鼠表现出显着增加，膈和舌下神经爆发振幅60分钟后，AIH显着大于对照实验没有AIH，表明在膈（分别为98%，56%和20%）和舌下神经LTF（分别为66%，77%和5%）的应变差异。F344和刘易斯的脊髓5-HT 2A受体mRNA和蛋白水平高于BN，表明较高的5-HT 2A受体水平与较高的pLTF相关。5-HT 7、BDNF和TrkB mRNA之间的关系更为复杂。与F344相比，BN具有更高的5-HT 7和TrkB mRNA;与F344相比，BN和刘易斯具有更高的BDNF mRNA水平。α能功能的遗传变异可能是AIH诱导的pLTF的菌株差异的基础。
We tested the hypotheses that: 1) long-term facilitation (LTF) following acute intermittent hypoxia (AIH) varies among three inbred rat strains: Fischer 344 (F344), Brown Norway (BN) and Lewis rats, and 2) ventral cervical spinal levels of genes important for phrenic LTF (pLTF) vary in association with pLTF magnitude. Lewis and F344, but not BN rats exhibited significant increases in phrenic and hypoglossal burst amplitude 60 min post-AIH that were significantly greater than control experiments without AIH, indicating strain differences in phrenic (98%, 56% and 20%, respectively) and hypoglossal LTF (66%, 77% and 5%, respectively). Ventral spinal 5-HT2A receptor mRNA and protein levels were higher in F344 and Lewis versus BN, suggesting that higher 5-HT2A receptor levels are associated with greater pLTF. More complex relationships were found for 5-HT7, BDNF and TrkB mRNA. BN had higher 5-HT7 and TrkB mRNA versus F344; BN and Lewis had higher BDNF mRNA levels versus F344. Genetic variations in serotonergic function may underlie strain differences in AIH-induced pLTF.
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DOI：
10.1016/s0034-5687(00)00124-9
发表时间：
2000-07-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Fuller, DD;Bach, KB;Mitchell, GS
通讯作者：
Mitchell, GS
影响因子：
2.3
作者：
Behan, M;Zabka, AG;Mitchell, GS
通讯作者：
Mitchell, GS
影响因子：
5.3
作者：
Golder, FJ;Mitchell, GS
通讯作者：
Mitchell, GS
影响因子：
5.5
作者：
Lee, Dorothy S.;Badr, M. Safwan;Mateika, Jason H.
通讯作者：
Mateika, Jason H.
影响因子：
2.5
作者：
Blitz, DM;Ramirez, JM
通讯作者：
Ramirez, JM