Progress of Periosteal Osteogenesis: The Prospect of In Vivo Bioreactor.
Progress of Periosteal Osteogenesis: The Prospect of In Vivo Bioreactor.
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骨膜成骨研究进展：体内生物反应器的前景
DOI：
10.1111/os.13325
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发表时间：
2022-09
影响因子：
2.1
通讯作者：
Wei, Jiao
中科院分区：
文献类型：
--
作者：
Chen, Xiaoxue;Yu, Baofu;Wang, Zi;Li, Qingfeng;Dai, Chuanchang;Wei, Jiao
修复大节段骨缺损仍是一个临床难题。骨组织预制具有巨大的转化潜力，已逐渐被临床所接受。现有的骨重建策略，包括自体骨膜移植、异体骨膜移植、异种骨膜移植、骨膜细胞组织工程等，都是具有临床价值的治疗方法，研究也取得了重大进展。本文综述了这些技术的研究进展，并简要阐述了体内微环境、机械力与骨膜成骨之间的关系。此外，我们还强调了骨膜在成骨中的关键作用的重要性，并解释了当前的挑战和未来的展望。本文综述了现有骨重建策略的研究进展，并简要阐述了体内微环境、机械力与骨膜成骨的关系。
Repairing large segment bone defects is still a clinical challenge. Bone tissue prefabrication shows great translational potentials and has been gradually accepted clinically. Existing bone reconstruction strategies, including autologous periosteal graft, allogeneic periosteal transplantation, xenogeneic periosteal transplantation, and periosteal cell tissue engineering, are all clinically valuable treatments and have made significant progress in research. Herein, we reviewed the research progress of these techniques and briefly explained the relationship among in vivo microenvironment, mechanical force, and periosteum osteogenesis. Moreover, we also highlighted the importance of the critical role of periosteum in osteogenesis and explained current challenges and future perspective. We reviewed the research progress of existing bone reconstruction strategies and briefly explained the relationship among in vivo microenvironment, mechanical force, and periosteum osteogenesis.
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