The evolutionary landscape of colorectal tumorigenesis.
The evolutionary landscape of colorectal tumorigenesis.
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DOI：
10.1038/s41559-018-0642-z
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发表时间：
2018-10
影响因子：
16.8
通讯作者：
Tomlinson IPM
中科院分区：
文献类型：
--
作者：
Cross W;Kovac M;Mustonen V;Temko D;Davis H;Baker AM;Biswas S;Arnold R;Chegwidden L;Gatenbee C;Anderson AR;Koelzer VH;Martinez P;Jiang X;Domingo E;Woodcock DJ;Feng Y;Kovacova M;Maughan T;S:CORT Consortium;Jansen M;Rodriguez-Justo M;Ashraf S;Guy R;Cunningham C;East JE;Wedge DC;Wang LM;Palles C;Heinimann K;Sottoriva A;Leedham SJ;Graham TA;Tomlinson IPM
导致结直肠腺瘤（良性）进展为癌（恶性）的进化事件在很大程度上仍未确定。使用24个良性和恶性结直肠肿瘤的多区域基因组/外显子组测序，我们探索这些肿瘤所占据的进化适应度景观。与癌不同，晚期腺瘤经常具有亚克隆驱动突变，其被认为在致癌过程中具有重要的功能，尚未被清除固定，并且具有相对较高的遗传异质性。癌与腺瘤的区别在于广泛的异染色体，异染色体通常是克隆的，并且经常以“间断”的方式累积。我们的结论是，腺瘤演变跨越起伏的健身景观，而癌占据了一个尖锐的健身峰，可能是由于稳定的选择。
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome/exome sequencing of 24 benign and malignant colorectal tumours, we probe the evolutionary fitness landscape occupied by these neoplasms. Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations, which are considered to be functionally important in the carcinogenic process, that have not swept to fixation, and have relatively high genetic heterogeneity. Carcinomas are distinguished from adenomas by widespread aneusomies that are usually clonal and often accrue in a “punctuated” fashion. We conclude that adenomas evolve across an undulating fitness landscape, whereas carcinomas occupy a sharper fitness peak, probably owing to stabilising selection.
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影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
影响因子：
64.5
作者：
Nik-Zainal S;Van Loo P;Wedge DC;Alexandrov LB;Greenman CD;Lau KW;Raine K;Jones D;Marshall J;Ramakrishna M;Shlien A;Cooke SL;Hinton J;Menzies A;Stebbings LA;Leroy C;Jia M;Rance R;Mudie LJ;Gamble SJ;Stephens PJ;McLaren S;Tarpey PS;Papaemmanuil E;Davies HR;Varela I;McBride DJ;Bignell GR;Leung K;Butler AP;Teague JW;Martin S;Jönsson G;Mariani O;Boyault S;Miron P;Fatima A;Langerød A;Aparicio SA;Tutt A;Sieuwerts AM;Borg Å;Thomas G;Salomon AV;Richardson AL;Børresen-Dale AL;Futreal PA;Stratton MR;Campbell PJ;Breast Cancer Working Group of the International Cancer Genome Consortium
通讯作者：
Breast Cancer Working Group of the International Cancer Genome Consortium
DOI：
10.1073/pnas.0712345105
发表时间：
2008-03-18
影响因子：
11.1
作者：
Jones, Sian;Chen, Wei-dong;Markowitz, Sanford D.
通讯作者：
Markowitz, Sanford D.
影响因子：
4.3
作者：
Blum, MGB;François, O
通讯作者：
François, O
影响因子：
30.8
作者：
Katainen, Riku;Dave, Kashyap;Aaltonen, Lauri A.
通讯作者：
Aaltonen, Lauri A.