Glucose intolerance and insulin resistance accompany immobilization.
Glucose intolerance and insulin resistance accompany immobilization.
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葡萄糖不耐症和胰岛素抵抗伴随着固定。
DOI：
10.1111/j.0954-6820.1987.tb09932.x
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发表时间：
2009
影响因子：
--
通讯作者：
E. Nikkilä
中科院分区：
文献类型：
--
作者：
P. Myllynen;V. Koivisto;E. Nikkilä
众所周知，体力活动会增加葡萄糖耐量和胰岛素敏感性。为了研究缺乏体力活动对胰岛素敏感性的影响，我们测定了18例急性脊柱骨折后卧床6周的患者的口服葡萄糖耐量（OGTT）和胰岛素对葡萄糖的反应。结果进行了比较，9个慢性固定脊髓损伤患者和8个健康的移动的控制。在创伤后的第一周，OGTT中的葡萄糖和胰岛素反应均高于正常值2 - 3倍（p <0.01）。胰岛素抵抗指数（葡萄糖面积×胰岛素面积）是健康对照组的7倍（p <0.001）。在三周的固定后，胰岛素抵抗下降了30-35%（p小于0.05），然后在长期固定的受试者中观察到的水平。再动员后，胰岛素抵抗进一步降低，但仍比对照组高2.3倍。因此，创伤引起胰岛素抵抗的多方面增加，其在随后的固定和再动员期间减少但不正常化。
Physical activity is known to increase glucose tolerance and insulin sensitivity. To examine the influence of physical inactivity on insulin sensitivity, we measured oral glucose tolerance (OGTT) and insulin response to glucose in 18 patients immobilized to bed for six weeks after acute spine fracture. The results were compared to those of nine chronically immobilized spinal cord injury patients and to eight healthy mobile controls. During the first week after trauma both glucose and insulin responses in the OGTT were two- to three-fold above normal (p less than 0.01). The index of insulin resistance (glucose area X insulin area) was seven-fold greater than in healthy controls (p less than 0.001). After three weeks' immobilization insulin resistance had declined by 30-35% (p less than 0.05) being then at the level observed in chronically immobilized subjects. After remobilization the insulin resistance was further decreased but remained still 2.3 times higher than in controls. Thus, trauma causes a manifold increase in insulin resistance, which is reduced but not normalized during the subsequent immobilization and remobilization.
肌肉萎缩对口服葡萄糖耐量测试的影响。
DOI：
10.1042/cs0640601
发表时间：
1983
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Moxley,RT;Griggs,RC;Forbes,GB;Goldblatt,D;Donohoe,K
通讯作者：
Donohoe,K
固定肢体肌肉中的葡萄糖摄取和糖原合成。
DOI：
10.1152/jappl.1984.56.2.431
发表时间：
1984
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Nicholson,WF;Watson,PA;Booth,FW
通讯作者：
Booth,FW