DHEA and testosterone in the elderly.
DHEA and testosterone in the elderly.
复制标题
老年人的 DHEA 和睾酮。
DOI：
10.1056/nejmc063190
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Bremner,WilliamJ
中科院分区：
文献类型：
--
作者：
Page,StephanieT;Matsumoto,AlvinM;Bremner,WilliamJ
To the Editor: In their report on the effects of dehydroepiandrosterone (DHEA) and testosterone when used as antiaging supplements, Nair et al.(Oct. 19 issue) 1 conclude that low-dose testosterone replacement in elderly men has no “physiologically relevant beneficial effects on body composition, physical performance,[or] insulin sensitivity.” However, this conclusion is premature, since the testosterone replacement administered failed to achieve physiologic testosterone levels throughout the study period (Fig. 2 of the article). Moreover, despite the marginal increase in testosterone levels achieved, improvements in fat-free mass, fasting insulin levels, and bone mineral density were observed.Other studies of testosterone replacement, including those cited to support the authors’ conclusions, 2 have shown a decrease in fat mass (12.5%) and an increase in lean mass (4%) when physiologic testosterone levels are achieved in elderly men. Studies of standard doses of testosterone in the treatment of testicular failure3 have shown additional positive effects on muscle strength, physical performance, 4 and bone mineral density. 5 Large, long-term trials are clearly needed to assess the risks and benefits of testosterone replacement in elderly men, and caution should be exercised regarding the treatment of andropause in men. However, the serum testosterone level achieved should be within the normal range to assess the effect on outcome measures adequately.
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DOI：
10.1210/jcem.84.8.5885
发表时间：
1999-08
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
P. Snyder;H. Peachey;P. Hannoush;J. Berlin;Louise Loh;D. Lenrow;J. Holmes;A. Dlewati;Jill Santanna;C. Rosen;B. Strom
通讯作者：
P. Snyder;H. Peachey;P. Hannoush;J. Berlin;Louise Loh;D. Lenrow;J. Holmes;A. Dlewati;Jill Santanna;C. Rosen;B. Strom
认知功能对老年人群功能状态的影响：马斯特里赫特老龄化研究的 3 年和 6 年随访
影响因子：
4
作者：
S. van Hooren;M. V. van Boxtel;Susanne A. M. Valentijn;H. Bosma;R. Ponds;J. Jolles
通讯作者：
J. Jolles
老年人运动训练的随机对照试验（仙台白银中心试验；SSCT）：研究设计和主要结果。
影响因子：
4.7
作者：
I. Tsuji;A. Tamagawa;R. Nagatomi;N. Irie;T. Ohkubo;M. Saito;K. Fujita;K. Ogawa;C. Sauvaget;Y. Anzai;A. Hozawa;Y. Watanabe;A. Sato;H. Ohmori;S. Hisamichi
通讯作者：
S. Hisamichi
影响因子：
5.8
作者：
Page, ST;Amory, JK;Tenover, JL
通讯作者：
Tenover, JL
影响因子：
158.5
作者：
Nair, K. Sreekumaran;Rizza, Robert A.;Jensen, Michael D.
通讯作者：
Jensen, Michael D.