On How the Dentate Gyrus Contributes to Memory Discrimination.
On How the Dentate Gyrus Contributes to Memory Discrimination.
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DOI：
10.1016/j.neuron.2018.04.018
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发表时间：
2018-05-16
期刊：
影响因子：
16.2
通讯作者：
Fenton AA
中科院分区：
文献类型：
--
作者：
van Dijk MT;Fenton AA
齿状回（DG）对于行为区分相似的空间记忆至关重要，它预测齿状回位置细胞改变（“重新映射”）空间调谐（“位置场”）以进行记忆区分。尽管 DG 在没有记忆任务的情况下在类似的环境中重新映射位置单元，但该预测从未经过测试。我们证实了这一先前的发现，但发现 DG 位置字段不会在需要依赖于 DG 的记忆辨别的空间任务之间重新映射。不是重新映射，而是在 DG 位置单元中短暂地观察到位置辨别放电，特别是当最需要记忆辨别时。 DG 网络可以通过在记忆辨别位点表达独特的亚秒级共射网络模式来发出记忆辨别信号。这涉及位置细胞和中间神经元放电耦合的增加，正如在成功但未失败的记忆辨别行为表达过程中观察到的那样。这些发现表明，记忆辨别不是重新映射，而是由齿状网络内相关放电的亚秒模式发出信号。 van Dijk 和 Fenton 报告说，齿状回位置细胞不是通过重新映射，而是通过协调位置细胞放电的可变亚秒模式来发出记忆辨别信号，其特征是记忆辨别过程中兴奋性和抑制性神经元之间的放电耦合增强。
The dentate gyrus (DG) is crucial for behaviorally discriminating similar spatial memories, predicting that dentate gyrus place cells change (“remap”) spatial tuning (“place fields”) for memory discrimination. This prediction was never tested, although DG place cells remap across similar environments without memory tasks. We confirm this prior finding but find that DG place fields do not remap across spatial tasks that require DG-dependent memory discrimination. Instead of remapping, place-discriminating discharge is observed transiently amongst DG place cells, particularly when memory discrimination is most necessary. The DG network may signal memory discrimination by expressing distinctive sub-second network patterns of co-firing at memory discrimination sites. This involves increased coupling of discharge from place cells and interneurons, as was observed during successful but not failed behavioral expression of memory discrimination. Instead of remapping, these findings indicate that memory discrimination is signaled by sub-second patterns of correlated discharge within the dentate network. van Dijk and Fenton report that dentate gyrus place cells signal memory discrimination not by remapping, but by variable sub-second patterns of coordinated place cell discharge marked by enhanced discharge coupling between excitatory and inhibitory neurons during memory discrimination.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
16.2
作者：
Danielson NB;Turi GF;Ladow M;Chavlis S;Petrantonakis PC;Poirazi P;Losonczy A
通讯作者：
Losonczy A
DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
DOI：
10.1073/pnas.95.6.3182
发表时间：
1998-03-17
影响因子：
11.1
作者：
Fenton, AA;Muller, RU
通讯作者：
Muller, RU
DOI：
10.1073/pnas.1421056111
发表时间：
2014-12-30
影响因子：
11.1
作者：
Alme, Charlotte B.;Miao, Chenglin;Moser, May-Britt
通讯作者：
Moser, May-Britt