Exposure to bisphenols and asthma morbidity among low-income urban children with asthma.
Exposure to bisphenols and asthma morbidity among low-income urban children with asthma.
复制标题
低收入城市哮喘儿童接触双酚和哮喘发病率。
DOI：
10.1016/j.jaci.2020.05.031
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Matsui EC
中科院分区：
文献类型：
--
作者：
Quirós-Alcalá L;Hansel NN;McCormack M;Calafat AM;Ye X;Peng RD;Matsui EC
Bisphenol A (BPA) has been linked with pediatric asthma development and allergic airway inflammation in animal models. Whether exposure to BPA or its structural analogues (BPS, BPF) is associated with asthma morbidity remains unknown. We examined associations between bisphenols and pediatric asthma morbidity. We quantified concentrations of BPA, BPS, and BPF in 660 urine samples from 148 predominantly low-income, African American children (5-17 years) with established asthma. We used biobanked biospecimens and data on symptoms, healthcare utilization, and pulmonary function and inflammation collected every 3 months over a year. We used generalized estimating equations to examine associations between concentrations or detection of urinary bisphenols and morbidity outcomes, and assessed heterogeneity of associations by sex. We observed consistent positive associations between BPA exposure and asthma morbidity measures. For example, we observed increased odds of general symptom days (adjusted Odds Ratio, aOR:1.40;95% Confidence Interval,95%CI:1.02, 1.92), maximal symptom days (aOR:1.36;95%CI:1.00, 1.83), and emergency department visits (aOR:2.12;95%CI:1.28, 3.51) per 10-fold increase in BPA concentrations. We also observed evidence of sexually dimorphic effects; BPA concentrations were associated with increased odds of symptom days and healthcare utilization only among boys. Findings with BPS and BPF did not consistently point to associations with asthma symptoms or healthcare utilization. We found evidence to suggest that BPA exposure in a predominantly low-income, minority pediatric cohort is associated with asthma morbidity and that associations may differ by sex. Our findings support additional studies given the high pediatric asthma burden and widespread exposure to BPA in the U.S. Exposure to bisphenol A, a xenoestrogen widely found in consumer products, was associated with increased asthma morbidity in a cohort of predominantly low-income, African American children with established asthma, especially among boys.
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DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
Chamacos队列中儿童期的产前和产后双酚A暴露和体重指数。
影响因子：
10.4
作者：
Harley KG;Aguilar Schall R;Chevrier J;Tyler K;Aguirre H;Bradman A;Holland NT;Lustig RH;Calafat AM;Eskenazi B
通讯作者：
Eskenazi B
DOI：
10.4168/aair.2010.2.3.183
发表时间：
2010-07
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Cho YS;Moon HB
通讯作者：
Moon HB
影响因子：
8.8
作者：
Hanioka, Nobumitsu;Naito, Takanori;Narimatsu, Shizuo
通讯作者：
Narimatsu, Shizuo
中国南方儿童的尿液中双酚类似物和三氯生及其对人类暴露的影响
影响因子：
8.9
作者：
Chen, Yi;Fang, Jianzhang;Lu, Shaoyou
通讯作者：
Lu, Shaoyou