Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort.
Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort.
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Chamacos队列中儿童期的产前和产后双酚A暴露和体重指数。
DOI：
10.1289/ehp.1205548
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发表时间：
2013-04
影响因子：
10.4
通讯作者：
Eskenazi B
中科院分区：
文献类型：
--
作者：
Harley KG;Aguilar Schall R;Chevrier J;Tyler K;Aguirre H;Bradman A;Holland NT;Lustig RH;Calafat AM;Eskenazi B
背景：双酚 A (BPA) 是一种广泛使用的内分泌干扰化学物质，与啮齿动物体重增加和脂肪沉积有关。目的：我们在 CHAMACOS 纵向队列研究中检查了 9 岁儿童 (n = 311) 的产前和产后尿 BPA 浓度是否与体重指数 (BMI)、腰围、体脂百分比和肥胖相关。方法：对两次怀孕期间母亲以及 5 岁和 9 岁儿童收集的点尿样本中的 BPA 进行测量。结果：产前尿 BPA 浓度与女孩 9 岁时体重指数下降相关，但与男孩无关。在女孩中，产前 BPA 浓度处于最高三分之一与 BMI z 得分（β = –0.47，95% CI：–0.87，–0.07）和体脂百分比（β = –4.36，95% CI：–8.37，–0.34）降低以及超重/肥胖几率降低相关[比值比 (OR) = 0.37，95% CI： 0.16, 0.91] 与最低三分位数的女孩相比。这些发现在青春期前的女孩中最为明显。 5 岁时尿液 BPA 浓度与 5 或 9 岁时的任何人体测量参数无关，但男孩和女孩 9 岁时的 BPA 浓度与 BMI、腰围、脂肪量和 9 岁时超重/肥胖呈正相关。结论：与其他横断面研究一致，9 岁时尿 BPA 浓度较高与 9 岁时肥胖增加相关。然而，母亲在怀孕期间 BPA 浓度的增加与女儿 9 岁时体重指数、体脂和超重/肥胖的降低有关。
Background: Bisphenol A (BPA), a widely used endocrine-disrupting chemical, has been associated with increased body weight and fat deposition in rodents. Objectives: We examined whether prenatal and postnatal urinary BPA concentrations were associated with body mass index (BMI), waist circumference, percent body fat, and obesity in 9-year-old children (n = 311) in the CHAMACOS longitudinal cohort study. Methods: BPA was measured in spot urine samples collected from mothers twice during pregnancy and from children at 5 and 9 years of age. Results: Prenatal urinary BPA concentrations were associated with decreased BMI at 9 years of age in girls but not boys. Among girls, being in the highest tertile of prenatal BPA concentrations was associated with decreased BMI z-score (β = –0.47, 95% CI: –0.87, –0.07) and percent body fat (β = –4.36, 95% CI: –8.37, –0.34) and decreased odds of overweight/obesity [odds ratio (OR) = 0.37, 95% CI: 0.16, 0.91] compared with girls in the lowest tertile. These findings were strongest in prepubertal girls. Urinary BPA concentrations at 5 years of age were not associated with any anthropometric parameters at 5 or 9 years, but BPA concentrations at 9 years were positively associated with BMI, waist circumference, fat mass, and overweight/obesity at 9 years in boys and girls. Conclusions: Consistent with other cross-sectional studies, higher urinary BPA concentrations at 9 years of age were associated with increased adiposity at 9 years. However, increasing BPA concentrations in mothers during pregnancy were associated with decreased BMI, body fat, and overweight/obesity among their daughters at 9 years of age.
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影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
男性和女性泌尿双酚A浓度的时间变异性和预测因子。
影响因子：
10.4
作者：
Mahalingaiah, Shruthi;Meeker, John D.;Pearson, Kimberly R.;Calafat, Antonia M.;Ye, Xiaoyun;Petrozza, John;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
10.4
作者：
Lubin JH;Colt JS;Camann D;Davis S;Cerhan JR;Severson RK;Bernstein L;Hartge P
通讯作者：
Hartge P
影响因子：
3.3
作者：
Newbold, Retha R.;Jefferson, Wendy N.;Padilla-Banks, Elizabeth
通讯作者：
Padilla-Banks, Elizabeth
影响因子：
1.2
作者：
Hiyama, Masato;Choi, Ehn-Kyong;Kiso, Yasuo
通讯作者：
Kiso, Yasuo