Genomic diversity across the Rickettsia and 'Candidatus Megaira' genera and proposal of genus status for the Torix group.
Genomic diversity across the Rickettsia and 'Candidatus Megaira' genera and proposal of genus status for the Torix group.
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DOI：
10.1038/s41467-022-30385-6
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发表时间：
2022-05-12
影响因子：
16.6
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中科院分区：
文献类型：
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细菌属立克次体的成员最初被确定为哺乳动物媒介传播疾病的病原体。然而，许多立克次体物种是节肢动物共生体，是微真核生物共生的‘Candidatus Megaira’的近亲。在这里，我们通过收集包括Torix群在内的未被研究的群体中的26个立克次体物种的基因组和两个‘Ca的基因组来阐明这些生物之间的进化关系。Megaira‘来自各种昆虫和微真核生物。我们对新基因组的分析表明，与以前描述的基因组相比，托里克斯立克次体的辅助基因组多样性和广泛的寄主范围与所有其他立克次体的总和相当。因此，Torix分支可能在无脊椎动物生物学和生理学中扮演着未被认识的角色。我们认为这个分支应该被赋予自己的属地位，为此，我们建议将其命名为‘Candidatus Tisiphia’。立克次体细菌属包括媒介传播的病原体和节肢动物共生体，它们是被归类为‘Candidatus Megaira’属的微型真核生物共生体的近亲。在这里，Davison等人。通过组合28个未被研究的物种的基因组来阐明这些生物之间的进化关系，并建议一个独特的支系，即Torix Rickettsia，应该被认为是一个单独的属。
Members of the bacterial genus Rickettsia were originally identified as causative agents of vector-borne diseases in mammals. However, many Rickettsia species are arthropod symbionts and close relatives of ‘Candidatus Megaira’, which are symbiotic associates of microeukaryotes. Here, we clarify the evolutionary relationships between these organisms by assembling 26 genomes of Rickettsia species from understudied groups, including the Torix group, and two genomes of ‘Ca. Megaira’ from various insects and microeukaryotes. Our analyses of the new genomes, in comparison with previously described ones, indicate that the accessory genome diversity and broad host range of Torix Rickettsia are comparable to those of all other Rickettsia combined. Therefore, the Torix clade may play unrecognized roles in invertebrate biology and physiology. We argue this clade should be given its own genus status, for which we propose the name ‘Candidatus Tisiphia’. The bacterial genus Rickettsia includes vector-borne pathogens and arthropod symbionts that are close relatives of symbionts of microeukaryotes classified under the genus ‘Candidatus Megaira’. Here, Davison et al. clarify the evolutionary relationships between these organisms by assembling 28 genomes of understudied species, and propose that a distinct clade known as Torix Rickettsia should be considered a separate genus.
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