Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study.
Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study.
复制标题
DOI：
10.3748/wjg.v24.i5.613
复制
发表时间：
2018-02-07
影响因子：
4.3
通讯作者：
de Mattos AA
中科院分区：
文献类型：
--
作者：
Marcon PDS;Tovo CV;Kliemann DA;Fisch P;de Mattos AA
评估乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）合并人类免疫缺陷病毒（HIV）引起的慢性肝病中肝细胞癌（HCC）的发生率。进行了一项回顾性队列研究，包括合并或不合并HIV感染的HBV或HCV引起的慢性肝病患者。患者于2007年1月至2014年6月在巴西南部最大的三级公立综合医院中选择。我们评估了人口统计和临床数据，包括生活习惯，如非法药物使用或酒精滥用，以及通过医疗记录审查入院的频率和原因。804例患者被纳入研究（399例合并HIV感染，405例合并HBV或HCV感染）。合并感染患者较年轻（36.7±10 vs 46.3±12.5,P < 0.001）。31.3%的hiv阴性患者出现肝硬化，16.5%的合并感染者出现肝硬化（P < 0.001）。36例患者被诊断为HCC（10例合并HIV感染，26例单独感染）。合并感染和单感染患者的HCC发病率密度分别为0.25和0.72例/ 100患者-年（95%CI: 0.12-0.46 vs 0.47-1.05）（长秩P = 0.002）。hiv阴性的HCC发病率比为2.98。然而，当调整年龄或仅分析肝硬化时，缺乏HIV对HCC的发展失去了统计学意义。在本研究中，HBV或HCV所致慢性肝病患者合并HIV感染与HCC发病率的增加无关。
To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV). A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014. We assessed demographic and clinical data, including lifestyle habits such as illicit drug use or alcohol abuse, in addition to frequency and reasons for hospital admissions via medical records review. Of 804 patients were included (399 with HIV coinfection and 405 monoinfected with HBV or HCV). Coinfected patients were younger (36.7 ± 10 vs 46.3 ± 12.5, P < 0.001). Liver cirrhosis was observed in 31.3% of HIV-negative patients and in 16.5% of coinfected (P < 0.001). HCC was diagnosed in 36 patients (10 HIV coinfected and 26 monoinfected). The incidence density of HCC in coinfected and monoinfected patients was 0.25 and 0.72 cases per 100 patient-years (95%CI: 0.12-0.46 vs 0.47-1.05) (long-rank P = 0.002), respectively. The ratio for the HCC incidence rate was 2.98 for HIV-negative. However, when adjusting for age or when only cirrhotic are analyzed, the absence of HIV lost statistical significance for the development of HCC. In this study, the presence of HIV coinfection in chronic liver disease due to HBV or HCV showed no relation to the increase of HCC incidence.
登录
查看更多内容
影响因子：
--
作者：
ANTONELLO, Vicente Sperb;ANTONELLO, Ivan Carlos Ferreira;TOVO, Cristiane Valle
通讯作者：
TOVO, Cristiane Valle
HAART 早期和晚期癌症发病率的变化模式：瑞士 HIV 队列研究。
影响因子：
8.8
作者：
Franceschi, S.;Lise, M.;Clifford, G. M.;Rickenbach, M.;Levi, F.;Maspoli, M.;Bouchardy, C.;Dehler, S.;Jundt, G.;Ess, S.;Bordoni, A.;Konzelmann, I.;Frick, H.;Dal Maso, L.;Elzi, L.;Furrer, H.;Calmy, A.;Cavassini, M.;Ledergerber, B.;Keiser, O.
通讯作者：
Keiser, O.
DOI：
10.5501/wjv.v4.i3.209
发表时间：
2015-08-12
期刊：
World journal of virology
影响因子：
--
作者：
Brugnaro, Pierluigi;Morelli, Erika;Raise, Enzo
通讯作者：
Raise, Enzo
影响因子：
3.8
作者：
Fassio, Eduardo;Diaz, Solangel;Pinchuk, Leonardo
通讯作者：
Pinchuk, Leonardo
影响因子：
1.5
作者：
Garcia-Garcia, Jose A.;Romero-Gomez, Manuel;Pineda, Juan A.
通讯作者：
Pineda, Juan A.