The spindle checkpoint and chromosome segregation in meiosis.
The spindle checkpoint and chromosome segregation in meiosis.
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DOI：
10.1111/febs.13166
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Gorbsky GJ
中科院分区：
文献类型：
--
作者：
Gorbsky GJ
纺锤体检查点是有丝分裂和减数分裂中染色体分离的关键调节因子。它的功能是防止早熟后期开始之前，染色体已经实现双极附着到纺锤体。纺锤体检查点包括一组复杂的信号传导途径，其整合微管动力学、着丝粒处的生物力学力以及蛋白质相互作用和翻译后修饰的复杂调节。从历史上看，许多关键的观察，引起了最初的概念，纺锤体检查点进行了减数分裂系统。与有丝分裂相反，减数分裂的两个不同的染色体分离事件对检查点信号的调节提出了特殊的挑战。由纺锤体检查点控制的减数分裂中染色体分离的保真度的保持也对人类健康有显著影响。本文综述了减数分裂系统在理解纺锤体检查点方面的贡献，以及检查点信号在控制减数分裂复杂分裂中的作用。
The spindle checkpoint is a key regulator of chromosome segregation in mitosis and meiosis. Its function is to prevent precocious anaphase onset before chromosomes have achieved bipolar attachment to the spindle. The spindle checkpoint comprises a complex set of signaling pathways that integrate microtubule dynamics, biomechanical forces at the kinetochores, and intricate regulation of protein interactions and post-translational modifications. Historically, many key observations that gave rise to the initial concepts of the spindle checkpoint were carried out in meiotic systems. In contrast with mitosis, the two distinct chromosome segregation events of meiosis present a special challenge for the regulation of checkpoint signaling. Preservation of fidelity in chromosome segregation in meiosis, controlled by the spindle checkpoint, also has significant impact in human health. This review highlights the contributions from meiotic systems in understanding the spindle checkpoint as well as the role of checkpoint signaling in controlling the complex divisions of meiosis.
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影响因子：
21.3
作者：
Basto, R;Gomes, R;Karess, RE
通讯作者：
Karess, RE
DOI：
10.1083/jcb.201303019
发表时间：
2013-07-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Davydenko O;Schultz RM;Lampson MA
通讯作者：
Lampson MA
影响因子：
64.5
作者：
EVANS, T;ROSENTHAL, ET;HUNT, T
通讯作者：
HUNT, T
DOI：
10.1159/000132871
发表时间：
1989-01-01
期刊：
CYTOGENETICS AND CELL GENETICS
影响因子：
--
作者：
EICHENLAUBRITTER, U;BOLL, I
通讯作者：
BOLL, I
影响因子：
4
作者：
Fragouli, Elpida;Alfarawati, Samer;Wells, Dagan
通讯作者：
Wells, Dagan