Response of neural reward regions to food cues in autism spectrum disorders.
Response of neural reward regions to food cues in autism spectrum disorders.
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DOI：
10.1186/1866-1955-4-9
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发表时间：
2012-05-17
影响因子：
4.9
通讯作者：
Cao A
中科院分区：
文献类型：
--
作者：
Cascio CJ;Foss-Feig JH;Heacock JL;Newsom CR;Cowan RL;Benningfield MM;Rogers BP;Cao A
关于自闭症谱系障碍 (ASD) 特征的社交缺陷的一种假设是对社交互动和依恋的神经奖励反应减弱。先前的研究使用既定的货币奖励范式作为非社会奖励的测试，以与社会奖励进行比较，这可能会涉及自闭症患者利用金钱的符号表示和解释金钱收益所需的抽象的能力的混淆。因此，对自闭症谱系障碍神经奖励回路的理解的一个有用补充包括对初级奖励的神经反应的表征。我们要求 17 名患有自闭症谱系障碍的儿童和 18 名没有自闭症谱系障碍的儿童在进行 MRI 扫描之前至少四个小时禁食，在扫描中他们会看到高热量食物的图像。我们评估了神经奖励网络响应食物图像的血氧水平依赖性（BOLD）信号的增加。我们发现两组中这些图像的 BOLD 信号增加的模式非常相似；两组患者的双侧杏仁核、伏隔核、眶额皮质和岛叶中的 BOLD 信号均增加。直接组间比较显示，自闭症谱系障碍组在双侧岛叶沿前后梯度和前扣带皮层中对食物线索的反应比对照组更强，而对照组没有神经奖励区域表现出比自闭症谱系障碍更高的激活。这些结果表明，自闭症谱系障碍儿童对主要奖励的神经反应并未减弱，反而表现出异常增强。
One hypothesis for the social deficits that characterize autism spectrum disorders (ASD) is diminished neural reward response to social interaction and attachment. Prior research using established monetary reward paradigms as a test of non-social reward to compare with social reward may involve confounds in the ability of individuals with ASD to utilize symbolic representation of money and the abstraction required to interpret monetary gains. Thus, a useful addition to our understanding of neural reward circuitry in ASD includes a characterization of the neural response to primary rewards. We asked 17 children with ASD and 18 children without ASD to abstain from eating for at least four hours before an MRI scan in which they viewed images of high-calorie foods. We assessed the neural reward network for increases in the blood oxygenation level dependent (BOLD) signal in response to the food images We found very similar patterns of increased BOLD signal to these images in the two groups; both groups showed increased BOLD signal in the bilateral amygdala, as well as in the nucleus accumbens, orbitofrontal cortex, and insula. Direct group comparisons revealed that the ASD group showed a stronger response to food cues in bilateral insula along the anterior-posterior gradient and in the anterior cingulate cortex than the control group, whereas there were no neural reward regions that showed higher activation for controls than for ASD. These results suggest that neural response to primary rewards is not diminished but in fact shows an aberrant enhancement in children with ASD.
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影响因子：
5.1
作者：
Bandini, Linda G.;Anderson, Sarah E.;Curtin, Carol;Cermak, Sharon;Evans, E. Whitney;Scampini, Renee;Maslin, Melissa;Must, Aviva
通讯作者：
Must, Aviva
DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Di Martino A;Shehzad Z;Kelly C;Roy AK;Gee DG;Uddin LQ;Gotimer K;Klein DF;Castellanos FX;Milham MP
通讯作者：
Milham MP
影响因子：
5.3
作者：
Bray, Signe;Rangel, Antonio;O'Doherty, John P.
通讯作者：
O'Doherty, John P.
影响因子：
5.7
作者：
Diedrichsen, J;Shadmehr, R
通讯作者：
Shadmehr, R
影响因子：
2.9
作者：
Finlayson, Graham;King, Neil;Blundell, John E.
通讯作者：
Blundell, John E.