The Role of the JC Virus in Central Nervous System Tumorigenesis.
The Role of the JC Virus in Central Nervous System Tumorigenesis.
复制标题
DOI：
10.3390/ijms21176236
复制
发表时间：
2020-08-28
影响因子：
5.6
通讯作者：
Wollebo HS
中科院分区：
文献类型：
--
作者：
Ahye N;Bellizzi A;May D;Wollebo HS
癌症是全球第二大死亡原因。DNA肿瘤诱导病毒及其癌蛋白作为癌症发生和肿瘤进展的致病因子的研究极大地提高了我们对癌细胞生物学的理解。肿瘤发生的起始是一个复杂的过程。特定的基因突变导致细胞的功能变化，最终导致无法有效地调节细胞分化和增殖。人类嗜神经性多瘤病毒JC（JCV）属于多瘤病毒科，是进行性多灶性白质脑病（PML）的病原体，PML是一种免疫抑制状态下的致命性神经退行性疾病。血清流行病学研究表明，JCV感染在人群中普遍存在（85%），初次感染通常发生在儿童时期。JC病毒具有小的环状双链DNA，其中包括病毒早期和晚期蛋白质的编码序列。这种病毒在大脑和其他组织中的持久性，以及它转化细胞的潜力，使其成为研究其在脑肿瘤发展中的作用的主题。早期观察到PML中的恶性星形胶质细胞和少突胶质细胞，以及接种JCV的非人灵长类动物中的胶质母细胞瘤形成，导致JCV在中枢神经系统（CNS）肿瘤发生中发挥作用的假设。一些研究报道了JC病毒DNA及其蛋白质在几个原发性脑肿瘤标本中的存在。新的多瘤病毒如与人类默克尔细胞癌相关的默克尔细胞多瘤病毒的发现，激发了我们对JC病毒在CNS肿瘤中的作用的兴趣。目前已知的关于JCV及其作用的证据足以在动物模型中产生肿瘤，表明它可能是中枢神经系统肿瘤发生的致病因素。然而，在CNS中存在的JCV与其在人类中引发CNS癌症和肿瘤形成的能力之间没有明确的关联。在这篇综述中，我们将讨论在动物模型中JCV和CNS肿瘤发生之间的相关性，我们将给出一个概述目前的证据JC病毒在脑肿瘤形成中的作用。
Cancer is the second leading cause of mortality worldwide. The study of DNA tumor-inducing viruses and their oncoproteins as a causative agent in cancer initiation and tumor progression has greatly enhanced our understanding of cancer cell biology. The initiation of oncogenesis is a complex process. Specific gene mutations cause functional changes in the cell that ultimately result in the inability to regulate cell differentiation and proliferation effectively. The human neurotropic Polyomavirus JC (JCV) belongs to the family Polyomaviridae and it is the causative agent of progressive multifocal leukoencephalopathy (PML), which is a fatal neurodegenerative disease in an immunosuppressed state. Sero-epidemiological studies have indicated JCV infection is prevalent in the population (85%) and that initial infection usually occurs during childhood. The JC virus has small circular, double-stranded DNA that includes coding sequences for viral early and late proteins. Persistence of the virus in the brain and other tissues, as well as its potential to transform cells, has made it a subject of study for its role in brain tumor development. Earlier observation of malignant astrocytes and oligodendrocytes in PML, as well as glioblastoma formation in non-human primates inoculated with JCV, led to the hypothesis that JCV plays a role in central nervous system (CNS) tumorigenesis. Some studies have reported the presence of both JC viral DNA and its proteins in several primary brain tumor specimens. The discovery of new Polyomaviruses such as the Merkel cell Polyomavirus, which is associated with Merkel cell carcinomas in humans, ignited our interest in the role of the JC virus in CNS tumors. The current evidence known about JCV and its effects, which are sufficient to produce tumors in animal models, suggest it can be a causative factor in central nervous system tumorigenesis. However, there is no clear association between JCV presence in CNS and its ability to initiate CNS cancer and tumor formation in humans. In this review, we will discuss the correlation between JCV and tumorigenesis of CNS in animal models, and we will give an overview of the current evidence for the JC virus’s role in brain tumor formation.
登录
查看更多内容
影响因子：
12.4
作者：
Gualco E;Urbanska K;Perez-Liz G;Sweet T;Peruzzi F;Reiss K;Del Valle L
通讯作者：
Del Valle L
影响因子：
3.6
作者：
Coyle-Rink, J;Del Valle, L;Amini, S
通讯作者：
Amini, S
影响因子：
6.4
作者：
Chapagain, Moti L.;Nerurkar, Vivek R.
通讯作者：
Nerurkar, Vivek R.
影响因子：
8
作者：
Bhattacharyya, R.;Noch, E. K.;Khalili, K.
通讯作者：
Khalili, K.
影响因子：
11.2
作者：
Chalkias, Spyridon;Dang, Xin;Bord, Evelyn;Stein, Marion C.;Kinkel, R. Philip;Sloane, Jacob A.;Donnelly, Maureen;Ionete, Carolina;Houtchens, Maria K.;Buckle, Guy J.;Batson, Stephanie;Koralnik, Igor J.
通讯作者：
Koralnik, Igor J.