Deformation of attractor landscape via cholinergic presynaptic modulations: a computational study using a phase neuron model.
Deformation of attractor landscape via cholinergic presynaptic modulations: a computational study using a phase neuron model.
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DOI：
10.1371/journal.pone.0053854
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Aihara K
中科院分区：
文献类型：
--
作者：
Kanamaru T;Fujii H;Aihara K
皮质乙酰胆碱（ACh）从Meynert基底核（NBM）短暂释放到皮质层，并与自上而下的注意力有关。最近的实验数据表明，ACh的释放通过毒蕈碱对抑制性突触的突触前效应抑制了2/3层锥体神经元（PYRs）。与其他可能的突触前胆碱能对兴奋性突触的影响一起，这可能导致与自上而下的注意相关的突触的动态和时间修饰。然而，这种去抑制的系统级后果和认知相关性尚不清楚。在此，我们提出了一种理论上的可能性，即除了自上而下的谷氨酸能输入外，这种与乙酰胆碱释放相关的连接的短暂改变可能为吸引子的时间再激活提供了一种神经机制，作为记忆的神经相关物。随着乙酰胆碱的基线水平，大脑返回到准吸引子状态，表现出几个内在内部状态之间的传递动态。这表明，自上而下的注意可能导致两种类型的吸引子景观之间的注意诱导变形：准吸引子景观（q -景观，存在于低乙酰氨基酸、非注意条件下）和吸引子景观（a -景观，存在于高乙酰氨基酸、自上而下的注意条件下）。我们提出了一个概念性的计算模型，该模型基于皮层1层和2/3层pyr和中间神经元（INs）结构的实验知识，并讨论了我们的结果可能的生理意义。
Corticopetal acetylcholine (ACh) is released transiently from the nucleus basalis of Meynert (NBM) into the cortical layers and is associated with top-down attention. Recent experimental data suggest that this release of ACh disinhibits layer 2/3 pyramidal neurons (PYRs) via muscarinic presynaptic effects on inhibitory synapses. Together with other possible presynaptic cholinergic effects on excitatory synapses, this may result in dynamic and temporal modifications of synapses associated with top-down attention. However, the system-level consequences and cognitive relevance of such disinhibitions are poorly understood. Herein, we propose a theoretical possibility that such transient modifications of connectivity associated with ACh release, in addition to top-down glutamatergic input, may provide a neural mechanism for the temporal reactivation of attractors as neural correlates of memories. With baseline levels of ACh, the brain returns to quasi-attractor states, exhibiting transitive dynamics between several intrinsic internal states. This suggests that top-down attention may cause the attention-induced deformations between two types of attractor landscapes: the quasi-attractor landscape (Q-landscape, present under low-ACh, non-attentional conditions) and the attractor landscape (A-landscape, present under high-ACh, top-down attentional conditions). We present a conceptual computational model based on experimental knowledge of the structure of PYRs and interneurons (INs) in cortical layers 1 and 2/3 and discuss the possible physiological implications of our results.
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影响因子：
25
作者：
Dantzker, JL;Callaway, EM
通讯作者：
Callaway, EM
DOI：
10.1016/s0079-6123(03)45015-2
发表时间：
2004-01-01
期刊：
ACETYLCHOLINE IN THE CEREBRAL CORTEX
影响因子：
--
作者：
Hasselmo, ME;McGaughy, J
通讯作者：
McGaughy, J
影响因子：
2.9
作者：
Ermentrout, B
通讯作者：
Ermentrout, B
影响因子：
16.2
作者：
Blatow, M;Rozov, A;Monyer, H
通讯作者：
Monyer, H
影响因子：
2.5
作者：
Christophe, E;Roebuck, A;Audinat, E
通讯作者：
Audinat, E