Inborn stress reactivity shapes adult behavioral consequences of early-life maternal separation stress.
Inborn stress reactivity shapes adult behavioral consequences of early-life maternal separation stress.
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DOI：
10.1016/j.neulet.2014.10.011
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发表时间：
2015-01-01
影响因子：
2.5
通讯作者：
Kerman IA
中科院分区：
文献类型：
--
作者：
Rana S;Pugh PC;Jackson N;Clinton SM;Kerman IA
早期生活经历强烈影响成年后的神经发育和压力易感性。母亲分离（MS）是一种早期生活逆境的既定模型，已被证明会对成年后的行为和内分泌应激反应产生负面影响。然而，多发性硬化症对先天应激易感性升高的大鼠的影响尚未得到充分探讨。为了解决这个问题，我们在Wistar-Kyoto（WKY）大鼠（抑郁和焦虑共病的动物模型）和Wistar大鼠（与WKY具有相似的遗传背景）中进行了MS。WKY和Wistar幼仔在出生后的前两周内经历了每天180分钟的MS或15分钟的分离（新生儿处理），并在成年期进行了抑郁和焦虑样行为测试。在WKY大鼠中暴露于早期生活MS减少了焦虑和抑郁样行为，导致在开放领域测试（OFT）中的探索增加，增强了社会互动，并在强迫游泳测试中减少了不动性。MS在Wistar后代中具有相反的效果，导致焦虑样行为增强，例如OFT探索减少和社会互动减少。这些发现与疾病的匹配/不匹配理论和预测性适应性反应一致，这表明早期生活压力暴露可以在某些个体的晚年生活中赋予适应性价值。我们的数据支持这一理论，表明早期生活的MS有积极的，也许是适应性的影响，在压力脆弱的WKY后代。未来的研究将需要阐明MS对WKY与Wistar后代的对比行为影响的神经生物学基础。
Early-life experience strongly impacts neurodevelopment and stress susceptibility in adulthood. Maternal separation (MS), an established model of early-life adversity, has been shown to negatively impact behavioral and endocrine responses to stress in adulthood. However, the impact of MS in rats with heightened inborn stress susceptibility has not been fully explored. To address this issue we conducted MS in Wistar-Kyoto (WKY) rats, an animal model of comorbid depression and anxiety, and Wistar rats, which share a similar genetic background with WKYs. WKY and Wistar pups experienced either 180-min daily MS or 15-min separation (neonatal handling) during the first two postnatal weeks, and were tested for depressive- and anxiety- like behaviors in adulthood. Exposure to early-life MS in WKY rats decreased anxiety- and depressive- like behaviors, leading to increased exploration on the open field test (OFT), enhanced social interaction, and diminished immobility on the forced swim test. MS had an opposite effect in Wistar offspring, leading to enhanced anxiety-like behaviors, such as reduced OFT exploration and decreased social interaction. These findings are consistent with the match/mismatch theory of disease and the predictive adaptive response, which suggest that early life stress exposure can confer adaptive value in later life within certain individuals. Our data supports this theory, showing that early-life MS has positive and perhaps adaptive effects within stress-vulnerable WKY offspring. Future studies will be required to elucidate the neurobiological underpinnings of contrasting behavioral effects of MS on WKY vs. Wistar offspring.
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影响因子：
5.3
作者：
Oomen, Charlotte A.;Soeters, Heleen;Krugers, Harm
通讯作者：
Krugers, Harm
DOI：
10.1016/0169-328x(93)90189-v
发表时间：
1993-05-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
PLOTSKY, PM;MEANEY, MJ
通讯作者：
MEANEY, MJ
影响因子：
168.9
作者：
Ravelli, ACJ;van der Meulen, JHP;Bleker, OP
通讯作者：
Bleker, OP
DOI：
10.1111/j.1469-7610.2006.01714.x
发表时间：
2007-03-01
影响因子：
7.6
作者：
Talge, Nicole M.;Neal, Charles;Glover, Vivette
通讯作者：
Glover, Vivette
影响因子：
5.6
作者：
Santarelli, Sara;Lesuis, Sylvie L.;Schmidt, Mathias V.
通讯作者：
Schmidt, Mathias V.