Interplay between the cancer genome and epigenome.
Interplay between the cancer genome and epigenome.
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DOI：
10.1016/j.cell.2013.03.008
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发表时间：
2013-03-28
期刊：
影响因子：
64.5
通讯作者：
Laird PW
中科院分区：
文献类型：
--
作者：
Shen H;Laird PW
癌症的产生是细胞生长控制的累积破坏的结果，达尔文选择那些提供最大克隆优势的遗传变化。这些性状可以通过遗传或表观遗传手段获得并稳定保持。在这里，我们探讨了基因组和表观基因组的改变相互影响和合作，以促进致癌转化的方式。表观基因组控制的破坏在恶性肿瘤中普遍存在，并且可以被归类为癌细胞的使能特征，类似于基因组不稳定性和突变。
Cancer arises as a consequence of cumulative disruptions to cellular growth control, with Darwinian selection for those heritable changes which provide the greatest clonal advantage. These traits can be acquired and stably maintained by either genetic or epigenetic means. Here we explore the ways in which alterations in the genome and epigenome influence each other and cooperate to promote oncogenic transformation. Disruption of epigenomic control is pervasive in malignancy, and can be classified as an enabling characteristic of cancer cells, akin to genome instability and mutation.
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影响因子：
50.3
作者：
De Carvalho DD;Sharma S;You JS;Su SF;Taberlay PC;Kelly TK;Yang X;Liang G;Jones PA
通讯作者：
Jones PA
影响因子：
50.3
作者：
Abdel-Wahab O;Adli M;LaFave LM;Gao J;Hricik T;Shih AH;Pandey S;Patel JP;Chung YR;Koche R;Perna F;Zhao X;Taylor JE;Park CY;Carroll M;Melnick A;Nimer SD;Jaffe JD;Aifantis I;Bernstein BE;Levine RL
通讯作者：
Levine RL
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
21.3
作者：
Coolen, Marcel W.;Stirzaker, Clare;Song, Jenny Z.;Statham, Aaron L.;Kassir, Zena;Moreno, Carlos S.;Young, Andrew N.;Varma, Vijay;Speed, Terence P.;Cowley, Mark;Lacaze, Paul;Kaplan, Warren;Robinson, Mark D.;Clark, Susan J.
通讯作者：
Clark, Susan J.
影响因子：
64.8
作者：
Berger, Michael F.;Lawrence, Michael S.;Demichelis, Francesca;Drier, Yotam;Cibulskis, Kristian;Sivachenko, Andrey Y.;Sboner, Andrea;Esgueva, Raquel;Pflueger, Dorothee;Sougnez, Carrie;Onofrio, Robert;Carter, Scott L.;Park, Kyung;Habegger, Lukas;Ambrogio, Lauren;Fennell, Timothy;Parkin, Melissa;Saksena, Gordon;Voet, Douglas;Ramos, Alex H.;Pugh, Trevor J.;Wilkinson, Jane;Fisher, Sheila;Winckler, Wendy;Mahan, Scott;Ardlie, Kristin;Baldwin, Jennifer;Simons, Jonathan W.;Kitabayashi, Naoki;MacDonald, Theresa Y.;Kantoff, Philip W.;Chin, Lynda;Gabriel, Stacey B.;Gerstein, Mark B.;Golub, Todd R.;Meyerson, Matthew;Tewari, Ashutosh;Lander, Eric S.;Getz, Gad;Rubin, Mark A.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.