Directing the assembly of spatially organized multicomponent tissues from the bottom up.
Directing the assembly of spatially organized multicomponent tissues from the bottom up.
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DOI：
10.1016/j.tcb.2012.09.004
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发表时间：
2012-12
影响因子：
19
通讯作者：
Gartner, Zev J.
中科院分区：
文献类型：
--
作者：
Liu, Jennifer S.;Gartner, Zev J.
人体的复杂性来自于在多个长度尺度上分层组装的众多模块化构建块。这些构建模块的大小从单个细胞到器官不等，它们相互作用以调节发育和正常的机体功能，但在疾病期间变得紊乱。在这里，我们回顾了自底向上和定向组装模块化，多细胞和体外组织样结构的方法。这些工程组织将有助于完善我们对人体形态和功能之间关系的理解，为伴随疾病的组织结构的破坏提供新的模型，并作为再生医学领域的基石。
The complexity of the human body derives from numerous modular building blocks assembled hierarchically across multiple length scales. These building blocks, spanning sizes ranging from single cells to organs, interact to regulate development and normal organismal function but become disorganized during disease. Here, we review methods for the bottom-up and directed assembly of modular, multicellular, and tissue-like constructs in vitro. These engineered tissues will help refine our understanding of the relationship between form and function in the human body, provide new models for the breakdown in tissue architecture that accompanies disease, and serve as building blocks for the field of regenerative medicine.
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