Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus.
Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus.
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DOI：
10.1051/vetres/2010046
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发表时间：
2010-09
影响因子：
4.4
通讯作者：
Montoya M
中科院分区：
文献类型：
--
作者：
Busquets N;Segalés J;Córdoba L;Mussá T;Crisci E;Martín-Valls GE;Simon-Grifé M;Pérez-Simó M;Pérez-Maíllo M;Núñez JI;Abad FX;Fraile L;Pina S;Majó N;Bensaid A;Domingo M;Montoya M
最近由2009年人类甲型H1N1流感病毒引起的大流行包含来自北美和欧亚猪血统以及禽流感和人类流感血统的祖先基因片段。2009年甲型H1N1流感病毒的出现对人类健康构成了潜在的全球威胁，而且它可以感染其他物种，如猪，这一事实有利于可能遇到在猪群中传播的其他流感病毒。在欧洲，H1N1、H1N2和H3N2亚型猪流感病毒目前在商业化养殖场中的流行率很高。为了更好地评估2009年甲型H1N1流感在养猪场的实际情况下构成的风险，我们试图分析先前感染欧洲流行的类似禽类的猪A/Swin/西班牙/53207/2004(H1N1)流感病毒(下称SWH1N1)是否对21天后再次感染新的人类大流行A/加泰罗尼亚/63/2009年(H1N1)流感病毒(下称PH1N1)产生交叉保护免疫。仅感染PH1N1的猪有轻到中度的病理结果，包括支气管间质性肺炎。然而，接种了SwH1N1病毒并随后感染了PH1N1的猪出现了非常轻微的肺部损害，显然是由于SwH1N1感染造成的其余损害。这些后来的猪也表现出了增强的特定抗体水平。最后，先感染SwH1N1病毒的动物和后来感染PH1N1病毒的动物在用PH1N1攻击后，在鼻拭子和肺中检测不到病毒RNA载量，表明两种毒株之间存在交叉保护作用。
The recent pandemic caused by human influenza virus A(H1N1) 2009 contains ancestral gene segments from North American and Eurasian swine lineages as well as from avian and human influenza lineages. The emergence of this A(H1N1) 2009 poses a potential global threat for human health and the fact that it can infect other species, like pigs, favours a possible encounter with other influenza viruses circulating in swine herds. In Europe, H1N1, H1N2 and H3N2 subtypes of swine influenza virus currently have a high prevalence in commercial farms. To better assess the risk posed by the A(H1N1) 2009 in the actual situation of swine farms, we sought to analyze whether a previous infection with a circulating European avian-like swine A/Swine/Spain/53207/2004 (H1N1) influenza virus (hereafter referred to as SwH1N1) generated or not cross-protective immunity against a subsequent infection with the new human pandemic A/Catalonia/63/2009 (H1N1) influenza virus (hereafter referred to as pH1N1) 21 days apart. Pigs infected only with pH1N1 had mild to moderate pathological findings, consisting on broncho-interstitial pneumonia. However, pigs inoculated with SwH1N1 virus and subsequently infected with pH1N1 had very mild lung lesions, apparently attributed to the remaining lesions caused by SwH1N1 infection. These later pigs also exhibited boosted levels of specific antibodies. Finally, animals firstly infected with SwH1N1 virus and latter infected with pH1N1 exhibited undetectable viral RNA load in nasal swabs and lungs after challenge with pH1N1, indicating a cross-protective effect between both strains.
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影响因子：
11.8
作者：
Kyriakis CS;Olsen CW;Carman S;Brown IH;Brookes SM;Doorsselaere JV;Reeth KV
通讯作者：
Reeth KV
影响因子：
5.4
作者：
Weingartl, Hana M.;Berhane, Yohannes;Pasick, John
通讯作者：
Pasick, John
影响因子：
3.8
作者：
Lange, Elke;Kalthoff, Donata;Vahlenkamp, Thomas W.
通讯作者：
Vahlenkamp, Thomas W.
影响因子：
4.8
作者：
Sreta D;Kedkovid R;Tuamsang S;Kitikoon P;Thanawongnuwech R
通讯作者：
Thanawongnuwech R
影响因子：
9.4
作者：
Spackman, E;Senne, DA;Suarez, DL
通讯作者：
Suarez, DL