The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus
The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus
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OB引起的抑郁对上矢状窦周围硬脑膜电刺激引起的伤害性行为的影响
DOI：
10.1016/j.brainres.2011.09.048
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发表时间：
2011-11
期刊：
影响因子：
2.9
通讯作者：
Li, Zheng
中科院分区：
文献类型：
--
作者：
Wang, Xiaolin;Liu, Ruozhuo;Chen, Xiaoyan;Li, Zheng
抑郁症和偏头痛之间的双向关系在流行病学和临床研究中已被广泛报道，但这些疾病之间的相互作用机制尚未使用动物模型进行充分研究。本研究旨在探讨嗅球切除术（OB）引起的抑郁对清醒大鼠三叉神经血管伤害性感受的影响。通过电刺激上级矢状窦（SSS）周围的硬脑膜诱导伤害性感受;该过程引起的伤害性感受与血管性头痛（如偏头痛）期间经历的伤害性感受相似。我们发现，与假手术（Sham）大鼠相比，OB大鼠的伤害性行为（梳理和甩头）显著增强，这些伤害性行为与抑郁样行为相关。全身给予抗抑郁药阿米替林（AMI）可显著减轻OB大鼠和Sham大鼠的伤害性行为。OB大鼠血浆P物质（SP）水平显著升高，而血浆降钙素基因相关蛋白（CGRP）水平未显著升高，AMI治疗后血浆SP水平降至正常。此外，血浆SP水平的变化与抑郁样行为和伤害性行为有关。总之，我们的研究结果表明，OB诱导的抑郁症可以加剧三叉神经血管的伤害性感受，这可能是由SP介导的。此外，我们表明，SP释放的抑制可能有助于AMI的抗伤害性感受作用。
A bi-directional relationship between depression and migraine has been widely reported in epidemiological and clinical studies, but the mechanisms of interaction between these disorders have not been fully examined using animal models. The aim of the present study was to investigate the effects of depression elicited by olfactory bulbectomy (OB) on trigeminovascular nociception in conscious rats. The nociception was induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus (SSS); this procedure causes nociception similar to that experienced during vascular headaches such as migraine. We showed that nociceptive behaviors (grooming and head flicks) were significantly enhanced in OB rats as compared to sham-operation (Sham) rats and that these nociceptive behaviors were correlated with depressive-like behaviors. Systemic administration of the antidepressant amitriptyline (AMI) significantly alleviated nociceptive behaviors in both the OB rats and Sham rats. Plasma levels of substance P (SP), but not plasma calcitonin gene-related protein (CGRP), significantly increased in OB rats and plasma SP levels decreased to normal following AMI treatment. Furthermore, changes in plasma SP levels were associated with both depressive-like behaviors and nociceptive behaviors. In conclusion, our results indicate that OB-induced depression can exacerbate trigeminovascular nociception, which may be mediated by SP. Moreover, we demonstrate that inhibition of SP release may contribute to the antinociceptive effect of AMI.
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影响因子：
3.7
作者：
Oláh Z;Jósvay K;Pecze L;Letoha T;Babai N;Budai D;Otvös F;Szalma S;Vizler C
通讯作者：
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作者：
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