Structure-Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles.
Structure-Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles.
复制标题
DOI：
10.1002/advs.202105373
复制
发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Kim KT
中科院分区：
文献类型：
--
作者：
De R;Mahata MK;Kim KT
携带者与毒品同等重要。它们可以显著提高货物的生物利用度，并保护健康细胞免受某些疗法的毒性影响。近年来，聚合物纳米载体(PNC)在将药物输送到细胞和亚细胞细胞器方面取得了巨大的成功。天然资源的多样性、不同合成路线的可用性、多样化的分子结构、可开发的物理化学性质、生物相容性和生物降解性使聚合物成为纳米载体设计最理想的材料之一。PNC相关纳米技术的最新创新概念和进展为设计纳米载体及其功能提供了前所未有的机会。治疗负荷的效率有了显著的提高。基于结构设计的各种PNC被广泛用于将小的治疗分子输送到基因和蛋白质。PNC获得了越来越多的关注，当然也为开发先进的纳米医学铺平了道路。本文介绍了基于结构设计的各种PNC及其物理化学性质对药物释放特性的影响，强调了在这一快速发展的领域中，将多刺激响应和多药物释放特性结合在一起以设计智能PNC作为新的和新兴的研究方向的必然性。易于设计各种结构的聚合物纳米载体(PNC)是其在生物医学中广泛应用的重要原因之一。本文重点介绍了基于结构的PNC的种类及其物理化学性质对其释药特性的影响。它还强调了使用多刺激响应性多药物递送PNC作为新的和新兴的研究方向。
Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to cells but also to subcellular organelles. Variety of natural sources, availability of different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, and biodegradability have presented polymers as one of the most desired materials for nanocarrier design. Recent innovative concepts and advances in PNC‐associated nanotechnology are providing unprecedented opportunities to engineer nanocarriers and their functions. The efficiency of therapeutic loading has got considerably increased. Structural design‐based varieties of PNCs are widely employed for the delivery of small therapeutic molecules to genes, and proteins. PNCs have gained ever‐increasing attention and certainly paves the way to develop advanced nanomedicines. This article presents a comprehensive investigation of structural design‐based varieties of PNCs and the influences of their physicochemical properties on drug delivery profiles with perspectives highlighting the inevitability of incorporating both the multi‐stimuli‐responsive and multi‐drug delivery properties in a single carrier to design intelligent PNCs as new and emerging research directions in this rapidly developing area. Ease of designing polymeric nanocarriers (PNCs) in various structures is one of the prominent reasons for their widespread use in biomedical applications. This review focuses on exploring structure‐based varieties of PNCs and influences of their physicochemical properties on their drug delivery profiles. It also highlights the use of multi‐stimuli responsive multi‐drug delivery PNCs as new and emerging research direction.
登录
查看更多内容
影响因子：
4.2
作者：
Anajafi T;Mallik S
通讯作者：
Mallik S
影响因子：
15
作者：
Battaglia, G;Ryan, AJ
通讯作者：
Ryan, AJ
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
4.6
作者：
Abandansari, Hamid Sadeghi;Abuali, Maryam;Niknejad, Hassan
通讯作者：
Niknejad, Hassan
影响因子：
4.6
作者：
Bütün, V
通讯作者：
Bütün, V