Is elevated SUA associated with a worse outcome in young Chinese patients with acute cerebral ischemic stroke?
Is elevated SUA associated with a worse outcome in young Chinese patients with acute cerebral ischemic stroke?
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DOI：
10.1186/1471-2377-10-82
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发表时间：
2010-09-18
期刊：
影响因子：
2.6
通讯作者：
Gao Q
中科院分区：
文献类型：
--
作者：
Zhang B;Gao C;Yang N;Zhang W;Song X;Yin J;Pu S;Yi Y;Gao Q
血清尿酸（SUA）水平升高可增强其抗氧化活性，减少脑梗死的发生。显著升高的SUA水平与脑梗死患者较好的预后相关；然而，一些关于SUA与脑梗死患者预后关系的研究结果仍存在争议。我们分析585例中国青年急性缺血性脑卒中患者出院时经改良Rankin量表测定的SUA与临床预后的关系。采用多变量logistic回归模型，探讨SUA水平与患者临床预后的关系。严重脑卒中患者入院时较低的SUA水平在最低五分位数中更为常见（P = 0.02）。小血管阻塞所致脑梗死患者的SUA浓度较高（P = 0.01）， mRS评分较低（P < 0.01），而心源性脑梗死患者的SUA浓度最低，mRS评分最高。经混杂因素校正后的Logistic回归分析证实了以下独立预测因子：尿酸（-0.003,95%CI 0.994 ~ 0.999）和血小板（0.004,95%CI 0.993 ~ 0.996）。SUA升高是年轻成人急性脑梗死良好临床预后的独立预测因子。
Elevated serum uric acid (SUA) levels can enhance its antioxidant prosperities and reduce the occurrence of cerebral infarction. Significantly elevated SUA levels have been associated with a better prognosis in patients with cerebral infarction; however, the results from some studies on the relationship between SUA and the prognosis of patients with cerebral infarction remain controversial. We analyzed the relationship between SUA and clinical prognosis of 585 young Chinese adults with acute ischemic stroke as determined by the modified Rankin Scale at discharge. Using multivariate logistic regression modeling, we explore the relationship between SUA levels and patient's clinical prognosis. Lower SUA levels at time of admission were observed more frequently in the lowest quintile for patients with severe stroke (P = 0.02). Patients with cerebral infarction patients caused by small-vessel blockage had higher SUA concentrations (P = 0.01) and the lower mRS scores (P < 0.01) were observed in, while the lowest SUA concentrations and the highest mRS scores were seen in patients with cardiogenic cerebral infarction patients. Logistic regression analysis adjusted for confounders confirmed the following independent predictors for young cerebral infarction: uric acid (-0.003: 95%CI 0.994 to 0.999) and platelet (0.004, 95%CI 0.993 to 0.996). Elevated SUA is an independent predictor for good clinical outcome of acute cerebral infarction among young adults.
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影响因子：
120.7
作者：
Fang, J;Alderman, MH
通讯作者：
Alderman, MH
影响因子：
5.3
作者：
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影响因子：
8.3
作者：
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影响因子：
8.3
作者：
Alderman, MH;Cohen, H;Kivlighn, S
通讯作者：
Kivlighn, S
影响因子：
3
作者：
Waring, WS;Webb, DJ;Maxwell, SRJ
通讯作者：
Maxwell, SRJ