The Impact of Cognitive Training on Cerebral White Matter in Community-Dwelling Elderly: One-Year Prospective Longitudinal Diffusion Tensor Imaging Study.
The Impact of Cognitive Training on Cerebral White Matter in Community-Dwelling Elderly: One-Year Prospective Longitudinal Diffusion Tensor Imaging Study.
复制标题
认知训练对社区老年人脑白质的影响：一年前瞻性纵向扩散张量成像研究
DOI：
10.1038/srep33212
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发表时间：
2016-09-15
影响因子：
4.6
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Cao X;Yao Y;Li T;Cheng Y;Feng W;Shen Y;Li Q;Jiang L;Wu W;Wang J;Sheng J;Feng J;Li C
研究表明，认知训练（CogTr）对老年人是有效的和恢复性的，可用于对抗认知能力下降。在这项研究中，我们调查了行为收益从CogTr是否会扩展到白色物质（WM）的微观结构，以及是否训练诱导的WM完整性的变化将与认知功能的改善，使用扩散张量成像（DTI）。48名健康的社区老年人被分配到多域或单域CogTr组，在12周内接受24次治疗，或对照组。在基线和12个月随访时进行DTI。多域CogTr对DTI指数的长期变化的积极影响被发现在后顶叶WM。多领域组的参与者显示出轴向扩散率（AD）长期下降的趋势，而各向异性分数（FA）、平均扩散率（MD）或径向扩散率（RD）没有显著变化，而对照组的参与者显示出FA显著下降，MD和RD增加。此外，在多领域组中发现了加工速度的改善与RD、MD和AD的变化之间的显著关系。这些研究结果支持的假设，即可塑性的WM可以修改CogTr，即使在成年后期。
It has been shown that cognitive training (CogTr) is effective and recuperative for older adults, and can be used to fight against cognitive decline. In this study, we investigated whether behavioural gains from CogTr would extend to white matter (WM) microstructure, and whether training-induced changes in WM integrity would be associated with improvements in cognitive function, using diffusion tensor imaging (DTI). 48 healthy community elderly were either assigned to multi-domain or single-domain CogTr groups to receive 24 sessions over 12 weeks, or to a control group. DTI was performed at both baseline and 12-month follow-up. Positive effects of multi-domain CogTr on long-term changes in DTI indices were found in posterior parietal WM. Participants in the multi-domain group showed a trend of long-term decrease in axial diffusivity (AD) without significant change in fractional anisotropy (FA), mean diffusivity (MD) or radial diffusivity (RD), while those in the control group displayed a significant FA decrease, and an increase in MD and RD. In addition, significant relationships between an improvement in processing speed and changes in RD, MD and AD were found in the multi-domain group. These findings support the hypothesis that plasticity of WM can be modified by CogTr, even in late adulthood.
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影响因子：
7.7
作者：
Kodl CT;Franc DT;Rao JP;Anderson FS;Thomas W;Mueller BA;Lim KO;Seaquist ER
通讯作者：
Seaquist ER
影响因子：
5.7
作者：
Barrick, Thomas R.;Charlton, Rebecca A.;Markus, Hugh S.
通讯作者：
Markus, Hugh S.
影响因子：
14.8
作者：
Bowie, Christopher R.;Harvey, Philip D.
通讯作者：
Harvey, Philip D.
DOI：
10.1177/1533317509332624
发表时间：
2009-06-01
影响因子：
3.4
作者：
Eckroth-Bucher, Margie;Siberski, James
通讯作者：
Siberski, James
DOI：
10.5114/aoms.2011.25561
发表时间：
2011-10
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Cheng Y;Wu W;Wang J;Feng W;Wu X;Li C
通讯作者：
Li C