Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function.
Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function.
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DOI：
10.2337/db08-0724
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发表时间：
2008-11
期刊：
影响因子：
7.7
通讯作者：
Seaquist ER
中科院分区：
文献类型：
--
作者：
Kodl CT;Franc DT;Rao JP;Anderson FS;Thomas W;Mueller BA;Lim KO;Seaquist ER
目的：长期存在的1型糖尿病与神经认知测试缺陷有关，这些缺陷提示中枢白质功能障碍。这项研究调查了扩散张量成像(DTI)--一种定量测量脑白质完整性的磁共振成像技术--是否可以识别长期存在的1型糖尿病患者的脑白质微结构缺陷，以及这些差异是否与神经认知测试发现的缺陷有关。研究设计和方法-25名患有1型糖尿病至少15年的受试者和25名年龄和性别匹配的对照组受试者在3.0特斯拉扫描仪上完成了DTI和一系列神经认知测试。计算了大脑主要白质束的分数各向异性。结果：糖尿病患者的后冠辐射和视神经辐射的平均分数各向异性显著低于对照组(P<；0.002)。在1型糖尿病患者中，分数各向异性降低与Rey-Osterreith复杂图形绘制测试和凹槽钉板测试的复制部分表现较差相关，这两项测试被认为都被认为是评估白质功能的。各向异性分数降低也与糖尿病病程和糖化血红蛋白升高有关。严重低血糖病史与分数各向异性无关。结论：DTI可以检测长期存在的1型糖尿病患者的脑白质微结构缺陷。这些缺陷与在选定的白质功能神经认知测试中表现较差有关。
OBJECTIVE—Long-standing type 1 diabetes is associated with deficits on neurocognitive testing that suggest central white matter dysfunction. This study investigated whether diffusion tensor imaging (DTI), a type of magnetic resonance imaging that measures white matter integrity quantitatively, could identify white matter microstructural deficits in patients with long-standing type 1 diabetes and whether these differences would be associated with deficits found by neurocognitive tests. RESEARCH DESIGN AND METHODS—Twenty-five subjects with type 1 diabetes for at least 15 years and 25 age- and sex-matched control subjects completed DTI on a 3.0 Tesla scanner and a battery of neurocognitive tests. Fractional anisotropy was calculated for the major white matter tracts of the brain. RESULTS—Diabetic subjects had significantly lower mean fractional anisotropy than control subjects in the posterior corona radiata and the optic radiation (P < 0.002). In type 1 diabetic subjects, reduced fractional anisotropy correlated with poorer performance on the copy portion of the Rey-Osterreith Complex Figure Drawing Test and the Grooved Peg Board Test, both of which are believed to assess white matter function. Reduced fractional anisotropy also correlated with duration of diabetes and increased A1C. A history of severe hypoglycemia did not correlate with fractional anisotropy. CONCLUSIONS—DTI can detect white matter microstructural deficits in subjects with long-standing type 1 diabetes. These deficits correlate with poorer performance on selected neurocognitive tests of white matter function.
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影响因子：
3.8
作者：
Khanzode, SD;Dakhale, GN;Palasodkar, R
通讯作者：
Palasodkar, R
影响因子：
16.2
作者：
Hershey, T;Bhargava, N;Craft, S
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Craft, S
影响因子：
7.7
作者：
Musen, G;Lyoo, IK;Jacobson, AM
通讯作者：
Jacobson, AM
影响因子：
10.6
作者：
Lim, KO;Choi, SJ;Rotrosen, JP
通讯作者：
Rotrosen, JP
影响因子：
7.6
作者：
Moeller, FG;Hasan, KM;Narayana, PA
通讯作者：
Narayana, PA