Blood Stasis Syndrome Accelerates the Growth and Metastasis of Breast Cancer by Promoting Hypoxia and Immunosuppressive Microenvironment in Mice.
Blood Stasis Syndrome Accelerates the Growth and Metastasis of Breast Cancer by Promoting Hypoxia and Immunosuppressive Microenvironment in Mice.
复制标题
血瘀证通过促进小鼠缺氧和免疫抑制微环境加速乳腺癌的生长和转移
DOI：
10.1155/2022/7222638
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发表时间：
2022
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
Blood stasis syndromes (BSSs) are closely related to the occurrence and development of tumors, although the mechanism is still unclear. This study was aimed at exploring the effect and mechanism underlying different BSSs on tumor growth and metastasis. We established four BSS mouse models bred with breast cancer: qi deficiency and blood stasis (QDBS), cold coagulation blood stasis (CCBS), heat toxin and blood stasis (HTBS), and qi stagnation and blood stasis (QSBS). The results showed that microcirculation in the lower limb, abdominal wall, and tumor in situ decreased by varying degrees in the BSS groups. In addition, BSS promoted tumor growth and lung metastasis. The ratio of regulatory T cells in the tumor microenvironment was downregulated. Moreover, hypoxia-inducible factor 1-α, Wnt1, β-catenin, vascular endothelial growth factor, and Cyclin D1 levels increased in the tumors of BSS mice. In conclusion, BSS not only promoted the formation of a hypoxic and immunosuppressive microenvironment but also promoted the neovascularization.
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影响因子：
8.8
作者：
Lee, H. E.;Park, D. J.;Kim, W. H.;Kim, H. H.;Lee, H. S.
通讯作者：
Lee, H. S.
影响因子：
24.8
作者：
Lee JC;Mehdizadeh S;Smith J;Young A;Mufazalov IA;Mowery CT;Daud A;Bluestone JA
通讯作者：
Bluestone JA
在外周血，病理特征和肺癌患者预后中，高凝状态与循环肿瘤细胞之间的关系。
DOI：
10.1155/2021/5732222
发表时间：
2021
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Jiao Y;Guo L;Wu L;Hu T
通讯作者：
Hu T
DOI：
10.1038/nrc3004
发表时间：
2011-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Gay LJ;Felding-Habermann B
通讯作者：
Felding-Habermann B
影响因子：
11.2
作者：
Im, JH;Fu, WL;Muschel, RJ
通讯作者：
Muschel, RJ