Contribution of platelets to tumour metastasis.

Contribution of platelets to tumour metastasis.
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DOI:
10.1038/nrc3004
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发表时间:
2011-03
期刊:
Nature reviews. Cancer
影响因子:
--
通讯作者:
Felding-Habermann B
Felding-Habermann B
中科院分区:
其他
文献类型:
--
作者:
Gay LJ;Felding-Habermann B

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大量实验证据表明血小板支持肿瘤转移。血小板和凝血系统的激活在癌症的进展中起着关键作用。在循环系统中,血小板保护肿瘤细胞免受免疫清除,并促进其在内皮细胞的抑制,支持继发性病变的建立。这些血小板对肿瘤细胞生存和扩散的贡献使血小板成为治疗的新途径。
Extensive experimental evidence shows that platelets support tumor metastasis. The activation of platelets and the coagulation system play a critical role in the progression of cancer. Within the circulatory system, platelets guard tumor cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondaruy lesions. These contributions of platelets to tumor cell survival and spread recognize platelets as a new avenue for therapy.
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