Crimean-Congo hemorrhagic fever in Turkey.

Crimean-Congo hemorrhagic fever in Turkey.
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DOI:
10.3201/eid1008.030928
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发表时间:
2004-08
影响因子:
11.8
通讯作者:
Ksiazek TG
Ksiazek TG
中科院分区:
医学2区
文献类型:
--
作者:
Karti SS;Odabasi Z;Korten V;Yilmaz M;Sonmez M;Caylan R;Akdogan E;Eren N;Koksal I;Ovali E;Erickson BR;Vincent MJ;Nichol ST;Comer JA;Rollin PE;Ksiazek TG

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土耳其报告19例疑似克里米亚-刚果出血热病例。2002年和2003年,土耳其共有19人出现克里米亚-刚果出血热或类似病毒感染的疑似病例。检测了6份血清样本;6例患者抗CCHF病毒免疫球蛋白M抗体均呈阳性。其中两个样本分离出CCHF病毒。病毒分离株的遗传分析表明,它们与来自前南斯拉夫和俄罗斯西南部的分离株密切相关。这些病例是土耳其报告的首批CCHF病例。18名患者处理牲畜,1名患者是护士,可能存在医院感染。在确诊的CCHF病例患者中,病死率为20%(5例患者中有1例),总病死率为11%(19例患者中有2例)。除了先前报道的症状和体征外,我们还报告了50%的患者出现噬血细胞症,这是首次报道这种与CCHF相关的临床现象。
Nineteen cases of suspected Crimean-Congo hemorrhagic fever reported from Turkey. In 2002 and 2003, a total of 19 persons in Turkey had suspected cases of Crimean-Congo hemorrhagic fever (CCHF) or a similar viral infection. Six serum samples were tested; all six were found positive for immunoglobulin M antibodies against CCHF virus. Two of the samples yielded CCHF virus isolates. Genetic analysis of the virus isolates showed them to be closely related to isolates from former Yugoslavia and southwestern Russia. These cases are the first of CCHF reported from Turkey. Eighteen patients handled livestock, and one was a nurse with probable nosocomial infection. The case-fatality rate was 20% among confirmed CCHF case-patients (1 of 5 patients), and the overall case-fatality rate was 11% (2 of 19 patients). In addition to previously reported symptoms and signs, we report hemophagocytosis in 50% of our patients, which is the first report of this clinical phenomenon associated with CCHF.
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