Influence of a long-term high-fat diet on ghrelin secretion and ghrelin-induced food intake in rats.
Influence of a long-term high-fat diet on ghrelin secretion and ghrelin-induced food intake in rats.
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DOI：
10.1016/j.regpep.2011.09.006
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发表时间：
2012-01-10
影响因子：
--
通讯作者：
Greeley GH Jr
中科院分区：
文献类型：
--
作者：
Gomez G;Han S;Englander EW;Greeley GH Jr
本研究的目的是：(1)确定长期高脂饮食在多大程度上降低了静息血浆胃饥饿素（总[酰基+去酰基]）水平和对空腹的血浆胃饥饿素（总）反应，(2)确定慢性高脂饮食是否改变了酰基胃饥饿素的供氧活性，(3)胰岛素预处理是否抑制了对空腹的血浆胃饥饿素（总）反应，(4)吡格列酮（PIO）治疗将在多大程度上增加饲喂HF饮食的大鼠胃和血浆胃饥饿素（总）水平。PIO是一种用于糖尿病患者的药物，可以改善胰岛素抵抗。我们的研究结果表明，慢性HF饮食给予10或60周对静息血浆胃饥饿素（总）水平有持续的抑制作用。此外，在长期喂食HF饮食的大鼠中，血浆胃饥饿素（总）升高并没有改变。HF饮食不影响对乙酰胃饥饿素的摄取反应。综上所述，这些结果表明酰基胃饥饿素是一个重要的促氧因子。结果表明，胰岛素预处理不会抑制空腹时血浆胃饥饿素（ghrelin, total）的反应，提示膳食诱导的胰岛素分泌不具有减少胃饥饿素（ghrelin, total）分泌的作用。在饲喂HF饮食的大鼠中，PIO增加了胃饥饿素（总）水平。由于PIO可以降低全身葡萄糖和脂质水平，我们的研究结果表明，葡萄糖和脂质水平升高是饲喂HF饮食的大鼠胃饥饿素（总）分泌减少的抑制机制的一部分。
The aims of this study were: (1) to define the extent to which a high-fat (HF) diet given on a long-term basis reduces resting plasma ghrelin (total [acyl + des-acyl]) levels and the plasma ghrelin (total) response to fasting, (2) to determine whether a chronic HF diet modifies the orexigenic activity of acyl-ghrelin, (3) whether insulin pretreatment inhibits the plasma ghrelin (total) response to fasting, and (4) the extent to which pioglitazone (PIO) treatment will increase stomach and plasma ghrelin (total) levels in rats fed a HF diet. PIO is a drug given to diabetics which improves insulin resistance. Our findings show that a chronic HF diet given for either 10 or 60 weeks exerts a persistent inhibitory effect on resting plasma ghrelin (total) levels. Additionally, the plasma ghrelin (total) elevation to overnight fasting is not altered in rats fed a HF diet on a long-term basis. A HF diet does not impair the ingestive response to acyl-ghrelin. Together, these results suggest that acyl-ghrelin serves as an important orexigenic factor. Results show that insulin pretreatment does not inhibit the plasma ghrelin (total) response to fasting suggesting that meal-induced insulin secretion does not have a role in reducing ghrelin (total) secretion. In rats fed a HF diet, PIO administration increases stomach ghrelin (total) levels. Because PIO can reduce systemic glucose and lipid levels, our findings suggest that elevated glucose and lipid levels are part of the inhibitory mechanism behind reduced ghrelin (total) secretion in rats fed a HF diet.
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影响因子：
29.4
作者：
Date, Y;Murakami, N;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
4.9
作者：
Perreault, M;Istrate, N;Stricker-Krongrad, A
通讯作者：
Stricker-Krongrad, A
DOI：
10.1152/ajpendo.90796.2008
发表时间：
2009-04-01
影响因子：
5.1
作者：
Paulino, Gabriel;de la Serre, Claire Barbier;Raybould, Helen E.
通讯作者：
Raybould, Helen E.
影响因子：
3.1
作者：
Huang, Chen-Ling;Hsu, Chung-Huei;Weng, Shuen-Fu
通讯作者：
Weng, Shuen-Fu
DOI：
10.1152/ajpregu.90329.2008
发表时间：
2008-08-01
影响因子：
2.8
作者：
Qi, Xiang;Reed, Jason T.;Greeley, George H., Jr.
通讯作者：
Greeley, George H., Jr.