Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients.
Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients.
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DOI：
10.1038/s41598-018-32720-8
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发表时间：
2018-10-02
影响因子：
4.6
通讯作者：
Fotopoulou C
中科院分区：
文献类型：
--
作者：
Cunnea P;Gorgy T;Petkos K;Gowers SAN;Lu H;Morera C;Wu W;Lawton P;Nixon K;Leong CL;Sorbi F;Domenici L;Paterson A;Curry E;Gabra H;Boutelle MG;Drakakis EM;Fotopoulou C
目前，没有有效的术前建立的生物标志物或算法可以准确预测晚期上皮性卵巢癌（EOC）患者的手术和临床结果。在这项研究中，我们建议通过电子传感器检测肿瘤参数，如生物电势和代谢物，可以促进未来设备的开发，以更好地监测疾病并预测手术和治疗结果。使用电位测量系统记录来自晚期EOC（n = 36）的离体配对的非癌性和癌性网膜组织中的生物电势，并收集裂解物用于通过微透析测量代谢物。在所有病例中，在癌组织与非癌组织中检测到一致的不同生物电势值（p < 0.001）。高肿瘤生物电位水平与晚期肿瘤分期（p = 0.048）和肿瘤负荷相关，与基质呈负相关。在我们的EOC队列中，特别是高级别浆液性亚型，低生物电位水平与无进展生存期较差相关（分别为p = 0.0179，p = 0.0143）。生物电位水平的变化与常见的凋亡相关通路显著相关。在成对组织中测量的乳酸和葡萄糖水平显示，在具有低生物电势的组织中，乳酸/葡萄糖比率显著更高（p < 0.01，n = 12）。我们的研究提出了生物电位和代谢物监测作为EOC生物标志物模式的可行性，以预测手术和临床结局。
Currently, there are no valid pre-operatively established biomarkers or algorithms that can accurately predict surgical and clinical outcome for patients with advanced epithelial ovarian cancer (EOC). In this study, we suggest that profiling of tumour parameters such as bioelectrical-potential and metabolites, detectable by electronic sensors, could facilitate the future development of devices to better monitor disease and predict surgical and treatment outcomes. Biopotential was recorded, using a potentiometric measurement system, in ex vivo paired non-cancerous and cancerous omental tissues from advanced stage EOC (n = 36), and lysates collected for metabolite measurement by microdialysis. Consistently different biopotential values were detected in cancerous tissue versus non-cancerous tissue across all cases (p < 0.001). High tumour biopotential levels correlated with advanced tumour stage (p = 0.048) and tumour load, and negatively correlated with stroma. Within our EOC cohort and specifically the high-grade serous subtype, low biopotential levels associated with poorer progression-free survival (p = 0.0179, p = 0.0143 respectively). Changes in biopotential levels significantly correlated with common apoptosis related pathways. Lactate and glucose levels measured in paired tissues showed significantly higher lactate/glucose ratio in tissues with low biopotential (p < 0.01, n = 12). Our study proposes the feasibility of biopotential and metabolite monitoring as a biomarker modality profiling EOC to predict surgical and clinical outcomes.
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影响因子：
4.6
作者：
Dong T;Liu Z;Xuan Q;Wang Z;Ma W;Zhang Q
通讯作者：
Zhang Q
影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
通讯作者：
Hamilton PW
DOI：
10.1038/nrc.2017.83
发表时间：
2017-11
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Mitchell MJ;Jain RK;Langer R
通讯作者：
Langer R
影响因子：
3.3
作者：
Levin M
通讯作者：
Levin M
DOI：
10.1038/nrc4019
发表时间：
2015-11
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Bowtell DD;Böhm S;Ahmed AA;Aspuria PJ;Bast RC Jr;Beral V;Berek JS;Birrer MJ;Blagden S;Bookman MA;Brenton JD;Chiappinelli KB;Martins FC;Coukos G;Drapkin R;Edmondson R;Fotopoulou C;Gabra H;Galon J;Gourley C;Heong V;Huntsman DG;Iwanicki M;Karlan BY;Kaye A;Lengyel E;Levine DA;Lu KH;McNeish IA;Menon U;Narod SA;Nelson BH;Nephew KP;Pharoah P;Powell DJ Jr;Ramos P;Romero IL;Scott CL;Sood AK;Stronach EA;Balkwill FR
通讯作者：
Balkwill FR